Issue 81, 2017
From the journal:

Chemical Communications

Enhanced cellular uptake and tumor penetration of nanoparticles by imprinting the “hidden” part of membrane receptors for targeted drug delivery†

Shan Peng,a   Yahua Wang,a   Na Lia  and  Chong Li ORCID logo *a  

* Corresponding authors

a College of Pharmaceutical Sciences, Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, Southwest University, Chongqing 400715, China
E-mail: chongli@swu.edu.cn

Abstract

The widely existing transmembrane helices can serve as a novel type of binding site for recognizing corresponding membrane receptors. Through imprinting the transmembrane domain of certain receptors, here we report the construction of polymeric nanoparticles which can achieve enhanced cellular uptake and permeability in target tissues for tumor-targeted drug delivery.

Graphical abstract: Enhanced cellular uptake and tumor penetration of nanoparticles by imprinting the “hidden” part of membrane receptors for targeted drug delivery

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Article information

DOI
https://doi.org/10.1039/C7CC05894B
Article type
Communication
Submitted
28 Jul 2017
Accepted
11 Sep 2017
First published
13 Sep 2017

Chem. Commun., 2017,53, 11114-11117

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Enhanced cellular uptake and tumor penetration of nanoparticles by imprinting the “hidden” part of membrane receptors for targeted drug delivery

S. Peng, Y. Wang, N. Li and C. Li, Chem. Commun., 2017, 53, 11114 DOI: 10.1039/C7CC05894B

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