-
Dual-energy lattice-tip ablation system for persistent atrial fibrillation: a randomized trial Nat. Med. (IF 82.9) Pub Date : 2024-05-17 Elad Anter, Moussa Mansour, Devi G. Nair, Dinesh Sharma, Tyler L. Taigen, Petr Neuzil, Erich L. Kiehl, Josef Kautzner, Jose Osorio, Stavros Mountantonakis, Andrea Natale, John D. Hummel, Anish K. Amin, Usman R. Siddiqui, Doron Harlev, Paul Hultz, Shufeng Liu, Birce Onal, Khaldoun G. Tarakji, Vivek Y. Reddy
-
Support services for healthcare professionals must be properly funded BMJ (IF 105.7) Pub Date : 2024-05-17 Harj K Kaul
Al-Najjar discusses the challenges of supporting medical practitioners with mental health problems through NHS Practitioner Health (NHSPH), formerly the practitioner health programme (PHP).1 NHSPH strives to provide support, treatment, and psychological safe places. I became an occupational medicine consultant in 2000 and over 80% of my clinics are for medical practitioners. Presentations are becoming
-
How to bridge innovation and regulation for responsible AI in healthcare Nat. Med. (IF 82.9) Pub Date : 2024-05-17 Brian Anderson
Quality assurance labs should independently test AI health tools.
-
A prognostic neural epigenetic signature in high-grade glioma Nat. Med. (IF 82.9) Pub Date : 2024-05-17 Richard Drexler, Robin Khatri, Thomas Sauvigny, Malte Mohme, Cecile L. Maire, Alice Ryba, Yahya Zghaibeh, Lasse Dührsen, Amanda Salviano-Silva, Katrin Lamszus, Manfred Westphal, Jens Gempt, Annika K. Wefers, Julia E. Neumann, Helena Bode, Fabian Hausmann, Tobias B. Huber, Stefan Bonn, Kerstin Jütten, Daniel Delev, Katharina J. Weber, Patrick N. Harter, Julia Onken, Peter Vajkoczy, David Capper, Benedikt
-
Prediction of DNA methylation-based tumor types from histopathology in central nervous system tumors with deep learning Nat. Med. (IF 82.9) Pub Date : 2024-05-17 Danh-Tai Hoang, Eldad D. Shulman, Rust Turakulov, Zied Abdullaev, Omkar Singh, Emma M. Campagnolo, H. Lalchungnunga, Eric A. Stone, MacLean P. Nasrallah, Eytan Ruppin, Kenneth Aldape
-
Integrative multi-omics profiling in human decedents receiving pig heart xenografts Nat. Med. (IF 82.9) Pub Date : 2024-05-17 Eloi Schmauch, Brian Piening, Maedeh Mohebnasab, Bo Xia, Chenchen Zhu, Jeffrey Stern, Weimin Zhang, Alexa K. Dowdell, Jacqueline I. Kim, David Andrijevic, Karen Khalil, Ian S. Jaffe, Bao-Li Loza, Loren Gragert, Brendan R. Camellato, Michelli F. Oliveira, Darragh P. O’Brien, Han M. Chen, Elaina Weldon, Hui Gao, Divya Gandla, Andrew Chang, Riyana Bhatt, Sarah Gao, Xiangping Lin, Kriyana P. Reddy, Larisa
-
p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial Nat. Med. (IF 82.9) Pub Date : 2024-05-17 Hayley R. C. Shanks, Kewei Chen, Eric M. Reiman, Kaj Blennow, Jeffrey L. Cummings, Stephen M. Massa, Frank M. Longo, Anne Börjesson-Hanson, Manfred Windisch, Taylor W. Schmitz
-
People who need insulin are particularly vulnerable in disasters and conflicts BMJ (IF 105.7) Pub Date : 2024-05-17 Alicia J Jenkins, Graham D Ogle, Renza Scibilia, Peter Schwarz, Frank P Brennan
Upholding international humanitarian law and ending the weaponisation of aid and medical supplies is critical to protecting the health of people with diabetes during disasters and conflicts, say Alicia J Jenkins and colleagues Globally, more than eight million people have type 1 diabetes (T1D) and need multiple daily insulin injections1 and many millions more have other forms of insulin requiring diabetes
-
Rhona MacDonald: medical editor and “a voice for those who could not be heard” BMJ (IF 105.7) Pub Date : 2024-05-17 Richard Smith
On the day she died Rhona MacDonald was working to have aid delivered to Ukraine, writing a letter to organise a medical evacuation from Gaza, and finalising a theme issue for the Bulletin of the World Health Organization . From the window of her home in Laide, a village on the coast of north west Scotland, she could see the sea, distant hills, birds in flight, and seals on the rocks. After she lost
-
Global child mortality falls to historic low BMJ (IF 105.7) Pub Date : 2024-05-17 Grace Irimu, Piyush Gupta, Mike English
Target to end preventable deaths among under 5s is within reach, UN data show The 2023 report of the United Nations Interagency Group for Child Mortality Estimation shows a remarkable 51% fall in global mortality for children aged under 5 years between 2000 and 2022, from 76 deaths/1000 live births to 37/1000.1 This is a historic low: millions more children are surviving as low and middle income countries
-
Effect of combination treatment with glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors on incidence of cardiovascular and serious renal events: population based cohort study BMJ (IF 105.7) Pub Date : 2024-05-16 British Medical Journal Publishing Group
In this paper by Simms-Williams and colleagues (BMJ 2024;385:e078242, doi:10.1136/bmj-2023-078242, published 25 April 2024), two greater than …
-
Effect of the HPV vaccination programme on incidence of cervical cancer and grade 3 cervical intraepithelial neoplasia by socioeconomic deprivation in England: population based observational study BMJ (IF 105.7) Pub Date : 2024-05-15 Milena Falcaro, Kate Soldan, Busani Ndlela, Peter Sasieni
Objectives To replicate previous analyses on the effectiveness of the English human papillomavirus (HPV) vaccination programme on incidence of cervical cancer and grade 3 cervical intraepithelial neoplasia (CIN3) using 12 additional months of follow-up, and to investigate effectiveness across levels of socioeconomic deprivation. Design Observational study. Setting England, UK. Participants Women aged
-
Clinical and healthcare use outcomes after cessation of long term opioid treatment due to prescriber workforce exit: quasi-experimental difference-in-differences study BMJ (IF 105.7) Pub Date : 2024-05-16 Adrienne H Sabety, Hannah T Neprash, Marema Gaye, Michael L Barnett
Objective To examine the association between prescriber workforce exit, long term opioid treatment discontinuation, and clinical outcomes. Design Quasi-experimental difference-in-differences study Setting 20% sample of US Medicare beneficiaries, 2011-18. Participants People receiving long term opioid treatment whose prescriber stopped providing office based patient care or exited the workforce, as
-
How could a radio broadcast on self-examination have avoided creating misperceptions? BMJ (IF 105.7) Pub Date : 2024-05-16 Richard Smith
Last week I listened to a radio broadcast in which a woman in her 20s with breast cancer described how she examined her breast and found a lump. She is now being treated for breast cancer. The interviewer, an older woman, interviewed her gently with empathy. There was no challenge, as there would have been to a politician, and the result was misleading and probably had some harmful messages. The peg
-
Drugs to help adults stop vaping … and other research BMJ (IF 105.7) Pub Date : 2024-05-16 Tom Nolan
Tom Nolan reviews this week’s research Over the past year we’ve seen various trials that assess vaping as an intervention for smoking cessation. Now we have smoking cessation drugs being studied as interventions to help people stop vaping. Cytisinicline, a plant based alkaloid that targets nicotinic acetylcholine receptors, has been available in the UK since the start of this year. One hundred and
-
Alasdair Geddes: infectious disease expert and bioterrorism adviser who diagnosed the world’s last reported case of smallpox BMJ (IF 105.7) Pub Date : 2024-05-16 John Illman
Alasdair Geddes recalled that his friends called him “a bit stupid” when he told them he was specialising in infectious disease. “They said, ‘You’re mad. Infectious diseases are disappearing. We have antibiotics and vaccines. Why don’t you do something more interesting?” he explained in the Lancet . Geddes, a modest, quiet but passionate doctor, went on to become president of the International Society
-
Protective power of plants . . . and other stories BMJ (IF 105.7) Pub Date : 2024-05-16 British Medical Journal Publishing Group
A longitudinal study of 2000 men with biopsy proved non-metastatic prostate cancer reports benefits from a plant based diet. Diet and lifestyle had been assessed soon after recruitment. During a median follow-up of 6.5 years, men scoring in the highest fifth for dietary intake of grains, fruits, legumes, and vegetables were only half as likely to experience disease progression as those in the lowest
-
A boat shaped bleed BMJ (IF 105.7) Pub Date : 2024-05-16 Ming An, Nianting Tong
This is a fundus image of the retina of a woman in her mid 60s with type 2 diabetes who presented with visual disturbances in her left eye (fig 1). She had been diagnosed with diabetes 15 years earlier and had an HbA1c levels consistently …
-
New death certification process: welcome changes in mindset, legislation, and hopefully data analysis BMJ (IF 105.7) Pub Date : 2024-05-16 Raj Bhopal
I welcome the renewed emphasis on the prevention of criminal activity as well as routine clinical investigation of the cause of death in the new death certification process.1 The rhetoric around medical murders—that this “must never happen again”—needs to be accompanied by stringent action. When certification of death by doctors was developed in the 19th century ruling out foul play was emphasised
-
Private Healthcare Information Network (PHIN): filling data gaps in independent sector BMJ (IF 105.7) Pub Date : 2024-05-16 Christopher Smith-Brown, Richard Wells
As Anderson and colleagues highlight,1 the Private Healthcare Information Network (PHIN) is mandated by the Competition and Markets Authority (CMA) Private Healthcare Investigation Order 20142 to publish performance and fee information about 645 hospitals and 12 000 consultants offering private inpatient services in the UK. We supply information to help patients make informed decisions. We agree that
-
“Excited delirium”: can the world lose this controversial term, which is accused of covering up deaths in police custody? BMJ (IF 105.7) Pub Date : 2024-05-15 Chris Stokel-Walker
Updating of medical guidance on the term has been brought forward, The BMJ learns, in the latest sign of the tide turning against its use. Chris Stokel-Walker explores whether “excited delirium” is ever fit for purpose—and what should happen next When George Floyd died in police custody in Minneapolis in May 2020, the circumstances of his death while being restrained became the focus of significant
-
HPV vaccine: the key to eliminating cervical cancer inequities BMJ (IF 105.7) Pub Date : 2024-05-15 Trisha L Amboree, Joslyn Paguio, Kalyani Sonawane
Programmes must ensure equitable access for all eligible groups The human papillomavirus (HPV) vaccine protects individuals from HPV strains that cause cancer. Evidence of its effectiveness in eliminating invasive cervical cancers is growing.1234 In a linked paper, Falcaro and colleagues (doi:10.1136/bmj-2023-077341) provide further evidence for the impact of HPV vaccination in eliminating invasive
-
Workplace rights around pregnancy and childbirth BMJ (IF 105.7) Pub Date : 2024-05-16 Amy Raub, Jody Heymann
Access to paid leave is a health and equity imperative On 15 April 2024, after a public consultation that received over 100 000 comments, the US Equal Employment Opportunity Commission (EEOC) issued final regulations detailing employers’ obligation to provide reasonable accommodation to pregnant workers.1 These new regulations expand access to unpaid time off as a reasonable accommodation during pregnancy
-
Who is accountable for the medical unemployment crisis? BMJ (IF 105.7) Pub Date : 2024-05-16 Kamran Abbasi
The story of vaccination against human papillomavirus in teenage girls is one of success. Cervical cancer rates have dropped markedly in all socioeconomic groups (doi:10.1136/bmj-2023-077341).1 An equitable implementation plan has achieved equitable benefits (doi:10.1136/bmj.q996).2 A less good health story is the murky use of dubious medical labels to deflect from unlawful death. “Excited delirium
-
“Inoculation” to Resist Misinformation JAMA (IF 120.7) Pub Date : 2024-05-16 Sander van der Linden, Jon Roozenbeek
This JAMA Insights in the Communicating Medicine series explores the concept of “prebunking,” a psychological inoculation technique that could help prevent the spread of misinformation.
-
Poison Ivy, Poison Oak, and Poison Sumac JAMA (IF 120.7) Pub Date : 2024-05-16 Lauren Weinberg, Preeti N. Malani
This JAMA Patient Page describes allergic skin reactions from contact with poison ivy, poison oak, and poison sumac plants, and how to treat rashes caused by these plants.
-
I Kept Crying JAMA (IF 120.7) Pub Date : 2024-05-16 Alexis Harmon
In this narrative medicine essay, a second-year pediatric resident bears the scars from the terror that descended the moment of her son’s birth at 31 weeks’ gestation, terror relived even after he has come home healthy.
-
Sex Differences in Primary Care–Based Chronic Kidney Disease Management JAMA (IF 120.7) Pub Date : 2024-05-16 Jorge A. Rodriguez, Sarah W. Chen, Chenxi Gao, Stuart R. Lipsitz, Mallika L. Mendu, Lipika Samal
This retrospective study uses electronic health record data to investigate the sex differences in guideline-based management outcomes between male and female patients with chronic kidney disease.
-
Heterologous prime-boost vaccination drives early maturation of HIV broadly neutralizing antibody precursors in humanized mice Sci. Transl. Med. (IF 17.1) Pub Date : 2024-05-16 Christopher A. Cottrell, Xiaozhen Hu, Jeong Hyun Lee, Patrick Skog, Sai Luo, Claudia T. Flynn, Katherine R. McKenney, Jonathan Hurtado, Oleksandr Kalyuzhniy, Alessia Liguori, Jordan R. Willis, Elise Landais, Sebastian Raemisch, Xuejun Chen, Sabyasachi Baboo, Sunny Himansu, Jolene K. Diedrich, Hongying Duan, Cheng Cheng, Torben Schiffner, Daniel L.V. Bader, Daniel W. Kulp, Ryan Tingle, Erik Georgeson
A protective human immunodeficiency virus (HIV) vaccine will likely need to induce broadly neutralizing antibodies (bnAbs). Vaccination with the germline-targeting immunogen eOD-GT8 60mer adjuvanted with AS01 B was found to induce VRC01-class bnAb precursors in 97% of vaccine recipients in the IAVI G001 phase 1 clinical trial; however, heterologous boost immunizations with antigens more similar to
-
Effectiveness of Bariatric Metabolic Surgery versus Glucagon-Like Peptide-1 Receptor Agonists for prevention of Congestive Heart Failure Nat. Med. (IF 82.9) Pub Date : 2024-05-15 Yael Wolff Sagy, Gil Lavie, Noga Ramot, Erez Battat, Ronen Arbel, Orna Reges, Dror Dicker
Comparative evidence for the effects of bariatric metabolic surgery (BMS) and glucagon-like peptide-1 receptor agonists (GLP1-RA) on cardiovascular outcomes is limited. Here, in an observational, retrospective cohort study, we compared the incidence of Congestive Heart Failure (CHF) in adults living with obesity and diabetes without history of CHF (primary CHF) treated with BMS versus GLP-1RA. The
-
The evolution of personalized nutrition Nat. Med. (IF 82.9) Pub Date : 2024-05-15 Josef Neu
Data from a large randomized trial show that a personalized diet can improve cardiometabolic health, providing support for a ‘food as medicine’ concept that, although centuries old, still lacks robust evidence.
-
Heat exposure induced risks of preterm birth mediated by maternal hypertension Nat. Med. (IF 82.9) Pub Date : 2024-05-15 Liyun Wang, Jiangli Di, Qiong Wang, Huanhuan Zhang, Wei Zhao, Xiaoming Shi, Qian Di, John S. Ji, Wannian Liang, Cunrui Huang
-
Senaparib as first-line maintenance therapy in advanced ovarian cancer: a randomized phase 3 trial Nat. Med. (IF 82.9) Pub Date : 2024-05-15 Xiaohua Wu, Jihong Liu, Jing Wang, Li Wang, Zhongqiu Lin, Xiaobin Wang, Jianqing Zhu, Beihua Kong, Junwei Fei, Ying Tang, Bairong Xia, Zhiqing Liang, Ke Wang, Yi Huang, Hong Zheng, An Lin, Kui Jiang, Wei Wang, Xin Wang, Ge Lou, Hongming Pan, Shuzhong Yao, Guiling Li, Min Hao, Yunlang Cai, Xuejun Chen, Zhijun Yang, Youguo Chen, Hongwu Wen, Pengpeng Qu, Cong Xu, Chih-Yi Hsieh
-
Long acting progestogens versus combined oral contraceptive pill for preventing recurrence of endometriosis related pain: the PRE-EMPT pragmatic, parallel group, open label, randomised controlled trial BMJ (IF 105.7) Pub Date : 2024-05-15 Kevin G Cooper, Siladitya Bhattacharya, Jane P Daniels, Andrew W Horne, T Justin Clark, Ertan Saridogan, Versha Cheed, Danielle Pirie, Melyda Melyda, Mark Monahan, Tracy E Roberts, Emma Cox, Clive Stubbs, Lee J Middleton
Objectives To evaluate the clinical effectiveness of long acting progestogens compared with the combined oral contraceptive pill in preventing recurrence of endometriosis related pain. Design The PRE-EMPT (preventing recurrence of endometriosis) pragmatic, parallel group, open label, randomised controlled trial. Setting 34 UK hospitals. Participants 405 women of reproductive age undergoing conservative
-
Equity in medical devices: trainers and educators play a vital role BMJ (IF 105.7) Pub Date : 2024-05-15 Margaret Whitehead, Enitan Carrol, Frank Kee, Raghib Ali, Chris Holmes
Education and training of healthcare professionals is essential to improve the systemwide problem of inequity in medical devices, say Margaret Whitehead and colleagues The impact of racial bias on the performance of medical devices used in the NHS gained public and political attention during the covid pandemic, with the recognition that patients with darker skin tones may be put at increased risk of
-
John Launer: Seeing the big picture—the distinctive value of generalism BMJ (IF 105.7) Pub Date : 2024-05-15 John Launer
Patients are often the beneficiaries of medicine, but they can be its victims too. Most people in the western world are likely to know by their 60s that they have at least one chronic condition or risk factor, if not several. As they age further the number of these will almost certainly increase, along with regular check-ups, investigations, and an escalating amount of treatment. Some of the effects
-
What do we know about covid-19’s effects on the brain? BMJ (IF 105.7) Pub Date : 2024-05-15 Katharine Lang
Katharine Lang investigates how SARS-CoV-2 infection can affect the brain, how it might have these effects, and what can be done to minimise the risk Covid may be primarily a respiratory infection, but a common symptom is “brain fog”—problems with memory or concentration—which can persist for weeks or months as part of long covid.1 And it’s not the only neurological effect. Giovanni Schifitto, professor
-
Cardiovascular toxicity of immune therapies for cancer BMJ (IF 105.7) Pub Date : 2024-05-15 Nicolas L Palaskas, Hyeon-Ju Ali, Efstratios Koutroumpakis, Sarju Ganatra, Anita Deswal
In addition to conventional chemoradiation and targeted cancer therapy, the use of immune based therapies, specifically immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T cell therapy (CAR-T), has increased exponentially across a wide spectrum of cancers. This has been paralleled by recognition of off-target immune related adverse events that can affect almost any organ system including
-
Blood Testing for Phosphatidylethanol JAMA (IF 120.7) Pub Date : 2024-05-15 Areej Mazhar, Amanda Cheung
A 36-year-old man with obesity and dyslipidemia presented with elevated liver enzymes following a liver transplant to treat acute-on-chronic liver failure due to alcohol-associated hepatitis. What would you do next?
-
Fosamax Fractures—Justice Has Not Been Served JAMA (IF 120.7) Pub Date : 2024-05-15 Gregory Curfman
This Viewpoint discusses the ongoing lawsuit between plaintiffs who had been affected by atypical femoral fractures while receiving alendronate and the drug manufacturer.
-
Mortality in Patients Hospitalized for COVID-19 vs Influenza in Fall-Winter 2023-2024 JAMA (IF 120.7) Pub Date : 2024-05-15 Yan Xie, Taeyoung Choi, Ziyad Al-Aly
This cohort study evaluates the risk of death in patients hospitalized for COVID-19 or seasonal influenza following the emergence of the JN.1 variant in winter 2023.
-
Neuronal population activity in the olivocerebellum encodes the frequency of essential tremor in mice and patients Sci. Transl. Med. (IF 17.1) Pub Date : 2024-05-15 Yi-Mei Wang, Chia-Wei Liu, Shun-Ying Chen, Liang-Yin Lu, Wen-Chuan Liu, Jia-Huei Wang, Chun-Lun Ni, Shi-Bing Wong, Ami Kumar, Jye-Chang Lee, Sheng-Han Kuo, Shun-Chi Wu, Ming-Kai Pan
Essential tremor (ET) is the most prevalent movement disorder, characterized primarily by action tremor, an involuntary rhythmic movement with a specific frequency. However, the neuronal mechanism underlying the coding of tremor frequency remains unexplored. Here, we used in vivo electrophysiology, optogenetics, and simultaneous motion tracking in the Grid2 dupE3 mouse model to investigate whether
-
SRC inhibition enables formation of a growth suppressive MAGI1-PP2A complex in isocitrate dehydrogenase-mutant cholangiocarcinoma Sci. Transl. Med. (IF 17.1) Pub Date : 2024-05-15 Iris S. Luk, Caroline M. Bridgwater, Angela Yu, Liberalis D. Boila, Mariana Yáñez-Bartolomé, Aaron E. Lampano, Taylor S. Hulahan, Myriam Boukhali, Meena Kathiresan, Teresa Macarulla, Heidi L. Kenerson, Naomi Yamamoto, David Sokolov, Ian A. Engstrom, Lucas B. Sullivan, Paul D. Lampe, Jonathan A. Cooper, Raymond S. Yeung, Tian V. Tian, Wilhelm Haas, Supriya K. Saha, Sita Kugel
Intrahepatic cholangiocarcinoma (ICC) is an aggressive bile duct malignancy that frequently exhibits isocitrate dehydrogenase ( IDH1/IDH2 ) mutations. Mutant IDH (IDHm) ICC is dependent on SRC kinase for growth and survival and is hypersensitive to inhibition by dasatinib, but the molecular mechanism underlying this sensitivity is unclear. We found that dasatinib reduced p70 S6 kinase (S6K) and ribosomal
-
Comparative analysis of SARS-CoV-2 neutralization titers reveals consistency between human and animal model serum and across assays Sci. Transl. Med. (IF 17.1) Pub Date : 2024-05-15 Barbara Mühlemann, Samuel H. Wilks, Lauren Baracco, Meriem Bekliz, Juan Manuel Carreño, Victor M. Corman, Meredith E. Davis-Gardner, Wanwisa Dejnirattisai, Michael S. Diamond, Daniel C. Douek, Christian Drosten, Isabella Eckerle, Venkata-Viswanadh Edara, Madison Ellis, Ron A. M. Fouchier, Matthew Frieman, Sucheta Godbole, Bart Haagmans, Peter J. Halfmann, Amy R. Henry, Terry C. Jones, Leah C. Katzelnick
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires ongoing monitoring to judge the ability of newly arising variants to escape the immune response. A surveillance system necessitates an understanding of differences in neutralization titers measured in different assays and using human and animal serum samples. We compared 18 datasets generated using human, hamster
-
Volumetric microscopy of cerebral arteries with a miniaturized optical coherence tomography imaging probe Sci. Transl. Med. (IF 17.1) Pub Date : 2024-05-15 Vitor M. Pereira, Pedro Lylyk, Nicole Cancelliere, Pedro N. Lylyk, Ivan Lylyk, Vania Anagnostakou, Carlos Bleise, Hidehisa Nishi, Mark Epshtein, Robert M. King, Mohammed Salman Shazeeb, Ajit S. Puri, Conrad W. Liang, Ricardo A. Hanel, Julian Spears, Thomas R. Marotta, Demetrius K. Lopes, Matthew J. Gounis, Giovanni J. Ughi
Endovascular interventions are increasingly becoming the preferred approach for treating strokes and cerebral artery diseases. These procedures rely on sophisticated angiographical imaging guidance, which encounters challenges because of limited contrast and spatial resolution. Achieving a more precise visualization of the underlying arterial pathology and neurovascular implants is crucial for accurate
-
Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis Sci. Transl. Med. (IF 17.1) Pub Date : 2024-05-15 Shi Yong Neo, Le Tong, Joni Chong, Yaxuan Liu, Xu Jing, Mariana M. S. Oliveira, Yi Chen, Ziqing Chen, Keene Lee, Nutsa Burduli, Xinsong Chen, Juan Gao, Ran Ma, Jia Pei Lim, Jianxin Huo, Shengli Xu, Evren Alici, Stina L. Wickström, Felix Haglund, Johan Hartman, Arnika K. Wagner, Yihai Cao, Rolf Kiessling, Kong Peng Lam, Lisa S. Westerberg, Andreas Lundqvist
Apart from their killer identity, natural killer (NK) cells have integral roles in shaping the tumor microenvironment. Through immune gene deconvolution, the present study revealed an interplay between NK cells and myeloid-derived suppressor cells (MDSCs) in nonresponders of immune checkpoint therapy. Given that the mechanisms governing the outcome of NK cell–to–myeloid cell interactions remain largely
-
Trastuzumab deruxtecan in HER2-positive advanced gastric cancer: exploratory biomarker analysis of the randomized, phase 2 DESTINY-Gastric01 trial Nat. Med. (IF 82.9) Pub Date : 2024-05-14 Kohei Shitara, Yung-Jue Bang, Satoru Iwasa, Naotoshi Sugimoto, Min-Hee Ryu, Daisuke Sakai, Hyun Cheol Chung, Hisato Kawakami, Hiroshi Yabusaki, Yasuhiro Sakamoto, Tomohiro Nishina, Koichiro Inaki, Yusuke Kuwahara, Naoya Wada, Fumitaka Suto, Takeo Arita, Masahiro Sugihara, Zenta Tsuchihashi, Kaku Saito, Akihito Kojima, Kensei Yamaguchi
-
Prevalence of comorbidities in individuals with neurodevelopmental disorders from the aggregated phenomics data of 51,227 pediatric individuals Nat. Med. (IF 82.9) Pub Date : 2024-05-14 Alexander J. M. Dingemans, Sandra Jansen, Jeroen van Reeuwijk, Nicole de Leeuw, Rolph Pfundt, Janneke Schuurs-Hoeijmakers, Bregje W. van Bon, Carlo Marcelis, Charlotte W. Ockeloen, Marjolein Willemsen, Pleuntje J. van der Sluijs, Gijs W. E. Santen, R. Frank Kooy, Anneke T. Vulto-van Silfhout, Tjitske Kleefstra, David A. Koolen, Lisenka E. L. M. Vissers, Bert B. A. de Vries
-
Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants Nat. Med. (IF 82.9) Pub Date : 2024-05-14 Md Shafiqur Rahman, Emma Harrison, Heather Biggs, Chloe Seikus, Paul Elliott, Gerome Breen, Nathalie Kingston, John R. Bradley, Steven M. Hill, Brian D. M. Tom, Patrick F. Chinnery
-
Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results Nat. Med. (IF 82.9) Pub Date : 2024-05-14 Jeffrey Sevigny, Olga Uspenskaya, Laura Dean Heckman, Li Chin Wong, Daniel A. Hatch, Ambika Tewari, Rik Vandenberghe, David J. Irwin, Dario Saracino, Isabelle Le Ber, Rebekah Ahmed, Jonathan D. Rohrer, Adam L. Boxer, Sebastian Boland, Patricia Sheehan, Alissa Brandes, Suzanne R. Burstein, Benjamin M. Shykind, Sitharthan Kamalakaran, Carter W. Daniels, E. David Litwack, Erin Mahoney, Jenny Velaga, Ilan
-
The efficacy of dapagliflozin in a hierarchical kidney outcome in heart failure Nat. Med. (IF 82.9) Pub Date : 2024-05-13
-
Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial Nat. Med. (IF 82.9) Pub Date : 2024-05-13 Donna H. Ryan, Ildiko Lingvay, John Deanfield, Steven E. Kahn, Eric Barros, Bartolome Burguera, Helen M. Colhoun, Cintia Cercato, Dror Dicker, Deborah B. Horn, G. Kees Hovingh, Ole Kleist Jeppesen, Alexander Kokkinos, A. Michael Lincoff, Sebastian M. Meyhöfer, Tugce Kalayci Oral, Jorge Plutzky, André P. van Beek, John P. H. Wilding, Robert F. Kushner
-
Sixty Years of Hemodynamic Pharmacology in Obstructive Hypertrophic Cardiomyopathy N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-13 Steve R. Ommen From the Department of Medicine, Mayo Clinic, Rochester, MN.
In April 1964, leading cardiologists, cardiovascular surgeons, and pathologists convened in London for a 2-day symposium to discuss a relatively new disease entity that we now know as obstructive h...
-
Aficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy N. Engl. J. Med. (IF 158.5) Pub Date : 2024-05-13 Martin S. Maron, Ahmad Masri, Michael E. Nassif, Roberto Barriales-Villa, Michael Arad, Nuno Cardim, Lubna Choudhury, Brian Claggett, Caroline J. Coats, Hans-Dirk Düngen, Pablo Garcia-Pavia, Albert A. Hagège, James L. Januzzi, Matthew M.Y. Lee, Gregory D. Lewis, Chang-Sheng Ma, Michelle Michels, Iacopo Olivotto, Artur Oreziak, Anjali T. Owens, John A. Spertus, Scott D. Solomon, Jacob Tfelt-Hansen,
One of the major determinants of exercise intolerance and limiting symptoms among patients with obstructive hypertrophic cardiomyopathy (HCM) is an elevated intracardiac pressure resulting from lef...
-
To increase public satisfaction in the NHS, we need a new conversation about how to improve it BMJ (IF 105.7) Pub Date : 2024-05-13 Jessie Cunnett, Richard Smith
As satisfaction with the NHS reaches a new low, we should embrace the power of citizens and society to restore public confidence , argue these authors The recent British Social Attitudes Survey found that less than a quarter (24%) of the 3374 respondents sampled in England, Wales, and Scotland were satisfied with the NHS—the lowest in the 41 year history of the survey.1 Since 2020, there has been an
-
Matt Morgan: Rekindling the NHS’s foundational flame BMJ (IF 105.7) Pub Date : 2024-05-14 Matt Morgan
One of the joys of writing this column is receiving emails from readers who work across a wide spectrum of medicine, from students to retired professors. I read one such email from a retired, fellow Cardiff alumnus in response to my last column discussing the new play Nye . After I’d watched the play at the National Theatre1—which dramatises the NHS’s origins through the eyes of Aneurin Bevan, former
-
The future of NHS primary care should focus on integration not fragmentation BMJ (IF 105.7) Pub Date : 2024-05-14 See Chai Carol Chan, Rebecca Wright, Azeem Majeed
In some parts of England, there are proposals to divide NHS primary care services. NHS England’s strategy aims to separate patients with “same-day” acute care or with “simpler” medical issues from patients with more complex, long term needs. The aim is to allow general practitioners (GPs) to primarily focus on the latter group of patients.12 While this approach appears superficially to be a rational
-
Helen Salisbury: Training our replacements BMJ (IF 105.7) Pub Date : 2024-05-14 Helen Salisbury
Are there limits on what people should be allowed to do in the medical or surgical field when they’re not a doctor and not training to be one? We teach someone our skills so that they may one day exercise them independently, and almost from the moment we qualify as doctors we start training our replacements. The time available for this training is finite, so we should think carefully about how we spend
-
The end of local clinical excellence awards BMJ (IF 105.7) Pub Date : 2024-05-14 Nick Murphy, Mark Exworthy, Julia Gauly, Jo Parsons, Katlyn Green
The news that consultants have accepted the government’s pay offer marks an important moment in British health policy, signalling the end of local clinical excellence awards (LCEAs) in England and Wales.1 The NHS has had a form of performance related pay for consultants since its inception. The 2003 consultant contract included the provision of locally administered awards for the delivery of “clinical
-
A lack of quality statistics is hiding the real heatwave death toll BMJ (IF 105.7) Pub Date : 2024-05-14 Disha Shetty
Heatwaves are intensifying but gaps in the data mean that the number of people who have died from rising temperatures is unclear. Disha Shetty reports on why—and why it matters Malaysia’s capital Kuala Lumpur is hot and humid throughout the year but this April temperatures rose to over 37°C compared with the usual low 30s. The tropical country’s meteorology department published a heatwave warning for