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Author Correction: A small and vigorous black hole in the early Universe Nature (IF 64.8) Pub Date : 2024-05-17 Roberto Maiolino, Jan Scholtz, Joris Witstok, Stefano Carniani, Francesco D’Eugenio, Anna de Graaff, Hannah Übler, Sandro Tacchella, Emma Curtis-Lake, Santiago Arribas, Andrew Bunker, Stéphane Charlot, Jacopo Chevallard, Mirko Curti, Tobias J. Looser, Michael V. Maseda, Timothy D. Rawle, Bruno Rodríguez del Pino, Chris J. Willott, Eiichi Egami, Daniel J. Eisenstein, Kevin N. Hainline, Brant Robertson
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How cheesemaking could cook up an antidote for alcohol excess Nature (IF 64.8) Pub Date : 2024-05-17
A gel made from a milk protein reduces alcohol levels in the blood of intoxicated mice.
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Pig-organ transplants: what three human recipients have taught scientists Nature (IF 64.8) Pub Date : 2024-05-17
As researchers mark the loss of the first living recipient of a pig kidney, they share what they’ve learnt about xenotransplantation.
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mRNA therapy is safe for treating the inherited metabolic condition propionic acidaemia Nature (IF 64.8) Pub Date : 2024-05-17
First-in-human clinical trial shows safety and promising signs of efficacy of mRNA therapy for rare but deadly genetic disease.
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Daniel Dennett obituary: ‘New atheism’ philosopher who sparked debate on consciousness Nature (IF 64.8) Pub Date : 2024-05-17
Cognitive scientist who boldly explored free will, the human mind and AI, and rejected the existence of God.
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More hints of Planet Nine Nat. Astron. (IF 14.1) Pub Date : 2024-05-17 Luca Maltagliati
One of the most debated issues in Solar System studies of the last decade is whether there is a massive body hidden beyond the orbit of Neptune, known as ‘Planet Nine’ (P9). Invisible to direct observations so far, its presence has been hinted at by its effects on the dynamics of the Trans-Neptunian Objects (TNO) population, and many works have been published to support or disprove the significance
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A bullying problem reveals an astronomy and geophysics community in crisis Nat. Astron. (IF 14.1) Pub Date : 2024-05-17 Áine Clare O’Brien, Sheila Kanani, Robert Massey, Natasha R. Stephen
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Reading between the lines: application essays predict university success Nature (IF 64.8) Pub Date : 2024-05-17
Applicants whose essays had broader ‘semantic content’ tended to achieve higher marks.
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Recycled sewage, public health and the memory of the world: Books in brief Nature (IF 64.8) Pub Date : 2024-05-17
Andrew Robinson reviews five of the best science picks.
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Could bird flu in cows lead to a human outbreak? Slow response worries scientists Nature (IF 64.8) Pub Date : 2024-05-17
The H5N1 virus is a long way from becoming adapted to humans, but limited testing and tracking mean we could miss danger signs.
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US halts funding to controversial virus-hunting group: what researchers think Nature (IF 64.8) Pub Date : 2024-05-16
Some scientists think the decision regarding EcoHealth Alliance is fair, while others say it might negatively impact virus surveillance.
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Found at last: long-lost branch of the Nile that ran by the pyramids Nature (IF 64.8) Pub Date : 2024-05-16
Geological survey reveals the remains of a major waterway that ancient Egyptian builders could have used to transport materials.
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Daily briefing: ‘Quantum internet’ demonstrated in three cities Nature (IF 64.8) Pub Date : 2024-05-16
Three research teams each created quantum-entangled states over several kilometres of existing optical fibres in real urban areas. Plus, lizard-inspired buildings could save lives and linguists are re-examining the idea that people are shaped by their native language.
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Gut microbes linked to fatty diet drive tumour growth Nature (IF 64.8) Pub Date : 2024-05-16
Scientists know there is a link between obesity and some cancers. A study in mice and people suggests why that might be.
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Daily briefing: How AI could help mathematicians achieve ‘moments of divine inspiration’ Nature (IF 64.8) Pub Date : 2024-05-15
Mathematical conjectures could be the ideal testing ground for AI-assisted discovery. Plus, why humans are so good at running and how to kill ‘zombie’ cells that make us age.
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Magnetism in massive stars from mergers Nat. Astron. (IF 14.1) Pub Date : 2024-05-16 Bishwanath Gaire
Magnetic fields in stars are mass dependent. Lower-mass stars like the Sun sustain a magnetic field, but only about 7% of the massive stars (with eight or more solar masses) have large-scale surface magnetic fields. The origin of such magnetic fields is unclear. Abigail Frost and colleagues investigate a binary system of two massive stars (HD 148937) using interferometric and spectroscopic methods
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Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines Nature (IF 64.8) Pub Date : 2024-05-15 Chieh-Yu Liang, Saravanan Raju, Zhuoming Liu, Yuhao Li, Guha Asthagiri Arunkumar, James Brett Case, Suzanne M. Scheaffer, Seth J. Zost, Cory M. Acreman, Matthew Gagne, Shayne F. Andrew, Deborah Carolina Carvalho dos Anjos, Kathryn E. Foulds, Jason S. McLellan, James E. Crowe, Daniel C. Douek, Sean P. J. Whelan, Sayda M. Elbashir, Darin K. Edwards, Michael S. Diamond
Immune imprinting is a phenomenon in which prior antigenic experiences influence responses to subsequent infection or vaccination1,2. The effects of immune imprinting on serum antibody responses after boosting with variant-matched SARS-CoV-2 vaccines remain uncertain. Here, we characterized the serum antibody responses after mRNA vaccine boosting of mice and human clinical trial participants. In mice
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Organoids merge to model the blood–brain barrier Nature (IF 64.8) Pub Date : 2024-05-15
Combining a brain organoid with a blood-vessel organoid yields a system similar to a protective mesh in the brain.
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Controlled failure: The building designed to limit catastrophe Nature (IF 64.8) Pub Date : 2024-05-15
New design - inspired by lizard tails - could save lives by isolating collapsing sections of damaged buildings
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Evolution of a novel adrenal cell type that promotes parental care Nature (IF 64.8) Pub Date : 2024-05-15 Natalie Niepoth, Jennifer R. Merritt, Michelle Uminski, Emily Lei, Victoria S. Esquibies, Ina B. Bando, Kimberly Hernandez, Christoph Gebhardt, Sarah A. Wacker, Stefano Lutzu, Asmita Poudel, Kiran K. Soma, Stephanie Rudolph, Andres Bendesky
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Suppressed thermal transport in silicon nanoribbons by inhomogeneous strain Nature (IF 64.8) Pub Date : 2024-05-15 Lin Yang, Shengying Yue, Yi Tao, Shuo Qiao, Hang Li, Zhaohe Dai, Bai Song, Yunfei Chen, Jinlong Du, Deyu Li, Peng Gao
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The rise of baobab trees in Madagascar Nature (IF 64.8) Pub Date : 2024-05-15 Jun-Nan Wan, Sheng-Wei Wang, Andrew R. Leitch, Ilia J. Leitch, Jian-Bo Jian, Zhang-Yan Wu, Hai-Ping Xin, Mijoro Rakotoarinivo, Guy Eric Onjalalaina, Robert Wahiti Gituru, Can Dai, Geoffrey Mwachala, Ming-Zhou Bai, Chen-Xi Zhao, Hong-Qi Wang, Sheng-Lan Du, Neng Wei, Guang-Wan Hu, Si-Chong Chen, Xiao-Ya Chen, Tao Wan, Qing-Feng Wang
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Arresting failure propagation in buildings through collapse isolation Nature (IF 64.8) Pub Date : 2024-05-15 Nirvan Makoond, Andri Setiawan, Manuel Buitrago, Jose M. Adam
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Dispersion-assisted high-dimensional photodetector Nature (IF 64.8) Pub Date : 2024-05-15 Yandong Fan, Weian Huang, Fei Zhu, Xingsi Liu, Chunqi Jin, Chenzi Guo, Yang An, Yuri Kivshar, Cheng-Wei Qiu, Wei Li
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GLP-1-directed NMDA receptor antagonism for obesity treatment Nature (IF 64.8) Pub Date : 2024-05-15 Jonas Petersen, Mette Q. Ludwig, Vaida Juozaityte, Pablo Ranea-Robles, Charlotte Svendsen, Eunsang Hwang, Amalie W. Kristensen, Nicole Fadahunsi, Jens Lund, Alberte W. Breum, Cecilie V. Mathiesen, Luisa Sachs, Roger Moreno-Justicia, Rebecca Rohlfs, James C. Ford, Jonathan D. Douros, Brian Finan, Bryan Portillo, Kyle Grose, Jacob E. Petersen, Mette Trauelsen, Annette Feuchtinger, Richard D. DiMarchi
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Photocatalytic doping of organic semiconductors Nature (IF 64.8) Pub Date : 2024-05-15 Wenlong Jin, Chi-Yuan Yang, Riccardo Pau, Qingqing Wang, Eelco K. Tekelenburg, Han-Yan Wu, Ziang Wu, Sang Young Jeong, Federico Pitzalis, Tiefeng Liu, Qiao He, Qifan Li, Jun-Da Huang, Renee Kroon, Martin Heeney, Han Young Woo, Andrea Mura, Alessandro Motta, Antonio Facchetti, Mats Fahlman, Maria Antonietta Loi, Simone Fabiano
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The temperature sensor TWA1 is required for thermotolerance in Arabidopsis Nature (IF 64.8) Pub Date : 2024-05-15 Lisa Bohn, Jin Huang, Susan Weidig, Zhenyu Yang, Christoph Heidersberger, Bernard Genty, Pascal Falter-Braun, Alexander Christmann, Erwin Grill
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Temporal multiplexing of perception and memory codes in IT cortex Nature (IF 64.8) Pub Date : 2024-05-15 Liang She, Marcus K. Benna, Yuelin Shi, Stefano Fusi, Doris Y. Tsao
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Superconducting diode effect and interference patterns in kagome CsV3Sb5 Nature (IF 64.8) Pub Date : 2024-05-15 Tian Le, Zhiming Pan, Zhuokai Xu, Jinjin Liu, Jialu Wang, Zhefeng Lou, Xiaohui Yang, Zhiwei Wang, Yugui Yao, Congjun Wu, Xiao Lin
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Physiological temperature drives TRPM4 ligand recognition and gating Nature (IF 64.8) Pub Date : 2024-05-15 Jinhong Hu, Sung Jin Park, Tyler Walter, Ian J. Orozco, Garrett O‘Dea, Xinyu Ye, Juan Du, Wei Lü
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Entanglement of nanophotonic quantum memory nodes in a telecom network Nature (IF 64.8) Pub Date : 2024-05-15 C. M. Knaut, A. Suleymanzade, Y.-C. Wei, D. R. Assumpcao, P.-J. Stas, Y. Q. Huan, B. Machielse, E. N. Knall, M. Sutula, G. Baranes, N. Sinclair, C. De-Eknamkul, D. S. Levonian, M. K. Bhaskar, H. Park, M. Lončar, M. D. Lukin
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Engineered CD47 protects T cells for enhanced antitumour immunity Nature (IF 64.8) Pub Date : 2024-05-15 Sean A. Yamada-Hunter, Johanna Theruvath, Brianna J. McIntosh, Katherine A. Freitas, Frank Lin, Molly T. Radosevich, Amaury Leruste, Shaurya Dhingra, Naiara Martinez-Velez, Peng Xu, Jing Huang, Alberto Delaidelli, Moksha H. Desai, Zinaida Good, Roel Polak, Audre May, Louai Labanieh, Jeremy Bjelajac, Tara Murty, Zach Ehlinger, Christopher W. Mount, Yiyun Chen, Sabine Heitzeneder, Kristopher D. Marjon
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Wavefunction matching for solving quantum many-body problems Nature (IF 64.8) Pub Date : 2024-05-15 Serdar Elhatisari, Lukas Bovermann, Yuan-Zhuo Ma, Evgeny Epelbaum, Dillon Frame, Fabian Hildenbrand, Myungkuk Kim, Youngman Kim, Hermann Krebs, Timo A. Lähde, Dean Lee, Ning Li, Bing-Nan Lu, Ulf-G. Meißner, Gautam Rupak, Shihang Shen, Young-Ho Song, Gianluca Stellin
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One-third of Southern Ocean productivity is supported by dust deposition Nature (IF 64.8) Pub Date : 2024-05-15 Jakob Weis, Zanna Chase, Christina Schallenberg, Peter G. Strutton, Andrew R. Bowie, Sonya L. Fiddes
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Decoding the interplay between genetic and non-genetic drivers of metastasis Nature (IF 64.8) Pub Date : 2024-05-15 Panagiotis Karras, James R. M. Black, Nicholas McGranahan, Jean-Christophe Marine
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A renewably sourced, circular photopolymer resin for additive manufacturing Nature (IF 64.8) Pub Date : 2024-05-15 Thiago O. Machado, Connor J. Stubbs, Viviane Chiaradia, Maher A. Alraddadi, Arianna Brandolese, Joshua C. Worch, Andrew P. Dove
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Volatile working memory representations crystallize with practice Nature (IF 64.8) Pub Date : 2024-05-15 Arash Bellafard, Ghazal Namvar, Jonathan C. Kao, Alipasha Vaziri, Peyman Golshani
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Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice Nature (IF 64.8) Pub Date : 2024-05-15 Gang Wang, Xi Chen, Chengzhi Yu, Xiaobao Shi, Wenxian Lan, Chaofeng Gao, Jun Yang, Huiling Dai, Xiaowei Zhang, Huili Zhang, Boyu Zhao, Qi Xie, Nan Yu, Zuhua He, Yu Zhang, Ertao Wang
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Dimerization and antidepressant recognition at noradrenaline transporter Nature (IF 64.8) Pub Date : 2024-05-15 Heng Zhang, Yu-Ling Yin, Antao Dai, Tianwei Zhang, Chao Zhang, Canrong Wu, Wen Hu, Xinheng He, Benxun Pan, Sanshan Jin, Qingning Yuan, Ming-Wei Wang, Dehua Yang, H. Eric Xu, Yi Jiang
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Creation of memory–memory entanglement in a metropolitan quantum network Nature (IF 64.8) Pub Date : 2024-05-15 Jian-Long Liu, Xi-Yu Luo, Yong Yu, Chao-Yang Wang, Bin Wang, Yi Hu, Jun Li, Ming-Yang Zheng, Bo Yao, Zi Yan, Da Teng, Jin-Wei Jiang, Xiao-Bing Liu, Xiu-Ping Xie, Jun Zhang, Qing-He Mao, Xiao Jiang, Qiang Zhang, Xiao-Hui Bao, Jian-Wei Pan
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Dual-action obesity drug rewires brain circuits for appetite Nature (IF 64.8) Pub Date : 2024-05-15 Tyler M. Cook, Darleen Sandoval
Two-in-one drug better than GLP-1 agonist alone at inducing weight loss.
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Strategic links save buildings from total collapse Nature (IF 64.8) Pub Date : 2024-05-15 Sarah L. Orton
Design strategy for preventing failure propagation in buildings.
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‘Quantum internet’ demonstration in cities is most advanced yet Nature (IF 64.8) Pub Date : 2024-05-15
Experiments generate quantum entanglement over optical fibres across three real cities, marking progress towards networks that could have revolutionary applications.
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Experimental obesity drug packs double punch to reduce weight Nature (IF 64.8) Pub Date : 2024-05-15
Test of weight-loss candidate in mice shows that there is still room for improvement in a burgeoning field.
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Parental-care puzzle in mice solved by thinking outside the brain Nature (IF 64.8) Pub Date : 2024-05-15 Jessica Tollkuhn
Previously unknown cell type found in mice that share parental care.
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Lizard-inspired building design could save lives Nature (IF 64.8) Pub Date : 2024-05-15
Hear the biggest stories from the world of science | 15 May 2024
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mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies Science (IF 56.9) Pub Date : 2024-05-16 Zhenfei Xie, Ying-Cing Lin, Jon M. Steichen, Gabriel Ozorowski, Sven Kratochvil, Rashmi Ray, Jonathan L. Torres, Alessia Liguori, Oleksandr Kalyuzhniy, Xuesong Wang, John E. Warner, Stephanie R. Weldon, Gordon A. Dale, Kathrin H. Kirsch, Usha Nair, Sabyasachi Baboo, Erik Georgeson, Yumiko Adachi, Michael Kubitz, Abigail M. Jackson, Sara T. Richey, Reid M. Volk, Jeong Hyun Lee, Jolene K. Diedrich, Thavaleak
Germline-targeting (GT) HIV vaccine strategies are predicated on deriving broadly neutralizing antibodies (bnAbs) through multiple boost immunogens. However, as the recruitment of memory B cells (MBCs) to germinal centers (GCs) is inefficient and may be derailed by serum antibody–induced epitope masking, driving further B cell receptor (BCR) modification in GC-experienced B cells after boosting poses
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An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wide gene delivery Science (IF 56.9) Pub Date : 2024-05-16 Qin Huang, Ken Y. Chan, Jason Wu, Nuria R. Botticello-Romero, Qingxia Zheng, Shan Lou, Casey Keyes, Alexander Svanbergsson, Jencilin Johnston, Allan Mills, Chin-Yen Lin, Pamela P. Brauer, Gabrielle Clouse, Simon Pacouret, John W. Harvey, Thomas Beddow, Jenna K. Hurley, Isabelle G. Tobey, Megan Powell, Albert T. Chen, Andrew J. Barry, Fatma-Elzahraa Eid, Yujia A. Chan, Benjamin E. Deverman
Developing vehicles that efficiently deliver genes throughout the human central nervous system (CNS) will broaden the range of treatable genetic diseases. We engineered an adeno-associated virus (AAV) capsid, BI-hTFR1, that binds human transferrin receptor (TfR1), a protein expressed on the blood-brain barrier (BBB). BI-hTFR1 was actively transported across human brain endothelial cells and, relative
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Diamond-lattice photonic crystals assembled from DNA origami Science (IF 56.9) Pub Date : 2024-05-16 Gregor Posnjak, Xin Yin, Paul Butler, Oliver Bienek, Mihir Dass, Seungwoo Lee, Ian D. Sharp, Tim Liedl
Colloidal self-assembly allows rational design of structures on the micrometer and submicrometer scale. One architecture that can generate complete three-dimensional photonic bandgaps is the diamond cubic lattice, which has remained difficult to realize at length scales comparable with the wavelength of visible or ultraviolet light. In this work, we demonstrate three-dimensional photonic crystals self-assembled
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Metabolic loads and the costs of metazoan reproduction Science (IF 56.9) Pub Date : 2024-05-16 Samuel C. Ginther, Hayley Cameron, Craig R. White, Dustin J. Marshall
Reproduction includes two energy investments—the energy in the offspring and the energy expended to make them. The former is well understood, whereas the latter is unquantified but often assumed to be small. Without understanding both investments, the true energy costs of reproduction are unknown. We present a framework for estimating the total energy costs of reproduction by combining data on the
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AlphaFold2 structures guide prospective ligand discovery Science (IF 56.9) Pub Date : 2024-05-16 Jiankun Lyu, Nicholas Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish K. Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey DiBerto, Kuglae Kim, Isabella S. Glenn, Tia A. Tummino, Sijie Huang, John J. Irwin, Olga O. Tarkhanova, Yurii Moroz, Georgios Skiniotis, Andrew C. Kruse, Brian K. Shoichet, Bryan L. Roth
AlphaFold2 (AF2) models have had wide impact, but they have had mixed success in retrospective ligand recognition. We prospectively docked large libraries against unrefined AF2 models of the σ2 and 5-HT2A receptors, testing hundreds of new molecules and comparing results to docking against the experimental structures. Hit rates were high and similar for the experimental and the AF2 structures, as were
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Global band convergence design for high-performance thermoelectric power generation in Zintls Science (IF 56.9) Pub Date : 2024-05-16 Xin Shi, Shaowei Song, Guanhui Gao, Zhifeng Ren
Electronic band convergence can have a beneficial impact on thermoelectric performance, but finding the right band-converged compositions is still time-consuming. We propose a method for designing a series of compositions with simultaneous band convergence in the high-entropy Yb x Ca 1− x Mg y Zn 2− y Sb 2 material by zeroing the weighted sum of crystal-field splitting energies of the parent compounds
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Tool use increases mechanical foraging success and tooth health in southern sea otters ( Enhydra lutris nereis ) Science (IF 56.9) Pub Date : 2024-05-16 Chris J. Law, M. Tim Tinker, Jessica A. Fujii, Teri Nicholson, Michelle Staedler, Joseph A. Tomoleoni, Colleen Young, Rita S. Mehta
Although tool use may enhance resource utilization, its fitness benefits are difficult to measure. By examining longitudinal data from 196 radio-tagged southern sea otters ( Enhydra lutris nereis ), we found that tool-using individuals, particularly females, gained access to larger and/or harder-shelled prey. These mechanical advantages translated to reduced tooth damage during food processing. We
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Delocalized, asynchronous, closed-loop discovery of organic laser emitters Science (IF 56.9) Pub Date : 2024-05-16 Felix Strieth-Kalthoff, Han Hao, Vandana Rathore, Joshua Derasp, Théophile Gaudin, Nicholas H. Angello, Martin Seifrid, Ekaterina Trushina, Mason Guy, Junliang Liu, Xun Tang, Masashi Mamada, Wesley Wang, Tuul Tsagaantsooj, Cyrille Lavigne, Robert Pollice, Tony C. Wu, Kazuhiro Hotta, Leticia Bodo, Shangyu Li, Mohammad Haddadnia, Agnieszka Wołos, Rafał Roszak, Cher Tian Ser, Carlota Bozal-Ginesta, Riley
Contemporary materials discovery requires intricate sequences of synthesis, formulation, and characterization that often span multiple locations with specialized expertise or instrumentation. To accelerate these workflows, we present a cloud-based strategy that enabled delocalized and asynchronous design-make-test-analyze cycles. We showcased this approach through the exploration of molecular gain
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DNA damage induces p53-independent apoptosis through ribosome stalling Science (IF 56.9) Pub Date : 2024-05-16 Nicolaas J. Boon, Rafaela A. Oliveira, Pierré-René Körner, Adva Kochavi, Sander Mertens, Yuval Malka, Rhianne Voogd, Suzanne E. M. van der Horst, Maarten A. Huismans, Lidwien P. Smabers, Jonne M. Draper, Lodewyk F. A. Wessels, Peter Haahr, Jeanine M. L. Roodhart, Ton N. M. Schumacher, Hugo J. Snippert, Reuven Agami, Thijn R. Brummelkamp
In response to excessive DNA damage, human cells can activate p53 to induce apoptosis. Cells lacking p53 can still undergo apoptosis upon DNA damage, yet the responsible pathways are unknown. We observed that p53-independent apoptosis in response to DNA damage coincided with translation inhibition, which was characterized by ribosome stalling on rare leucine-encoding UUA codons and globally curtailed
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Inverse design of a pyrochlore lattice of DNA origami through model-driven experiments Science (IF 56.9) Pub Date : 2024-05-16 Hao Liu, Michael Matthies, John Russo, Lorenzo Rovigatti, Raghu Pradeep Narayanan, Thong Diep, Daniel McKeen, Oleg Gang, Nicholas Stephanopoulos, Francesco Sciortino, Hao Yan, Flavio Romano, Petr Šulc
Sophisticated statistical mechanics approaches and human intuition have demonstrated the possibility of self-assembling complex lattices or finite-size constructs. However, attempts so far have mostly only been successful in silico and often fail in experiment because of unpredicted traps associated with kinetic slowing down (gelation, glass transition) and competing ordered structures. Theoretical
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Enantioselective remote methylene C−H (hetero)arylation of cycloalkane carboxylic acids Science (IF 56.9) Pub Date : 2024-05-16 Tao Zhang, Zi-Yu Zhang, Guowei Kang, Tao Sheng, Jie-Lun Yan, Yuan-Bin Yang, Yuxin Ouyang, Jin-Quan Yu
Stereoselective construction of γ- and δ-stereocenters in carbonyl compounds is a pivotal objective in asymmetric synthesis. Here, we report chiral bifunctional oxazoline-pyridone ligands that enable enantioselective palladium-catalyzed remote γ-C−H (hetero)arylations of free cycloalkane carboxylic acids, which are essential carbocyclic building blocks in organic synthesis. The reaction establishes
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How power shapes behavior: Evidence from physicians Science (IF 56.9) Pub Date : 2024-05-16 Stephen D. Schwab, Manasvini Singh
Power—the asymmetric control of valued resources—affects most human interactions. Although power is challenging to study with real-world data, a distinctive dataset allowed us to do so within the critical context of doctor-patient relationships. Using 1.5 million quasi-random assignments in US military emergency departments, we examined how power differentials between doctor and patient (measured by
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Remote proton elimination: C–H activation enabled by distal acidification Science (IF 56.9) Pub Date : 2024-05-16 Phillip S. Grant, Miloš Vavrík, Vincent Porte, Ricardo Meyrelles, Nuno Maulide
Generally, the acidity of carbon-hydrogen bonds is most sensitive to functionality just one or two bonds away. Here, we present an approach to the formation of carbon-carbon σ bonds by remote proton elimination, a distinct mode of carbon-hydrogen activation enabled by distal acidification through five carbon-carbon bonds. Application of remote proton elimination to cyclodecyl cations unveiled an appealing
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Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates Science (IF 56.9) Pub Date : 2024-05-16 Jon M. Steichen, Ivy Phung, Eugenia Salcedo, Gabriel Ozorowski, Jordan R. Willis, Sabyasachi Baboo, Alessia Liguori, Christopher A. Cottrell, Jonathan L. Torres, Patrick J. Madden, Krystal M. Ma, Henry J. Sutton, Jeong Hyun Lee, Oleksandr Kalyuzhniy, Joel D. Allen, Oscar L. Rodriguez, Yumiko Adachi, Tina-Marie Mullen, Erik Georgeson, Michael Kubitz, Alison Burns, Shawn Barman, Rohini Mopuri, Amanda
Germline-targeting immunogens hold promise for initiating the induction of broadly neutralizing antibodies (bnAbs) to HIV and other pathogens. However, antibody-antigen recognition is typically dominated by heavy chain complementarity determining region 3 (HCDR3) interactions, and vaccine priming of HCDR3-dominant bnAbs by germline-targeting immunogens has not been demonstrated in humans or outbred