-
Author Correction: A small and vigorous black hole in the early Universe Nature (IF 64.8) Pub Date : 2024-05-17 Roberto Maiolino, Jan Scholtz, Joris Witstok, Stefano Carniani, Francesco D’Eugenio, Anna de Graaff, Hannah Übler, Sandro Tacchella, Emma Curtis-Lake, Santiago Arribas, Andrew Bunker, Stéphane Charlot, Jacopo Chevallard, Mirko Curti, Tobias J. Looser, Michael V. Maseda, Timothy D. Rawle, Bruno Rodríguez del Pino, Chris J. Willott, Eiichi Egami, Daniel J. Eisenstein, Kevin N. Hainline, Brant Robertson
-
How cheesemaking could cook up an antidote for alcohol excess Nature (IF 64.8) Pub Date : 2024-05-17
A gel made from a milk protein reduces alcohol levels in the blood of intoxicated mice.
-
Pig-organ transplants: what three human recipients have taught scientists Nature (IF 64.8) Pub Date : 2024-05-17
As researchers mark the loss of the first living recipient of a pig kidney, they share what they’ve learnt about xenotransplantation.
-
mRNA therapy is safe for treating the inherited metabolic condition propionic acidaemia Nature (IF 64.8) Pub Date : 2024-05-17
First-in-human clinical trial shows safety and promising signs of efficacy of mRNA therapy for rare but deadly genetic disease.
-
Daniel Dennett obituary: ‘New atheism’ philosopher who sparked debate on consciousness Nature (IF 64.8) Pub Date : 2024-05-17
Cognitive scientist who boldly explored free will, the human mind and AI, and rejected the existence of God.
-
Reading between the lines: application essays predict university success Nature (IF 64.8) Pub Date : 2024-05-17
Applicants whose essays had broader ‘semantic content’ tended to achieve higher marks.
-
Recycled sewage, public health and the memory of the world: Books in brief Nature (IF 64.8) Pub Date : 2024-05-17
Andrew Robinson reviews five of the best science picks.
-
Could bird flu in cows lead to a human outbreak? Slow response worries scientists Nature (IF 64.8) Pub Date : 2024-05-17
The H5N1 virus is a long way from becoming adapted to humans, but limited testing and tracking mean we could miss danger signs.
-
US halts funding to controversial virus-hunting group: what researchers think Nature (IF 64.8) Pub Date : 2024-05-16
Some scientists think the decision regarding EcoHealth Alliance is fair, while others say it might negatively impact virus surveillance.
-
Found at last: long-lost branch of the Nile that ran by the pyramids Nature (IF 64.8) Pub Date : 2024-05-16
Geological survey reveals the remains of a major waterway that ancient Egyptian builders could have used to transport materials.
-
Daily briefing: ‘Quantum internet’ demonstrated in three cities Nature (IF 64.8) Pub Date : 2024-05-16
Three research teams each created quantum-entangled states over several kilometres of existing optical fibres in real urban areas. Plus, lizard-inspired buildings could save lives and linguists are re-examining the idea that people are shaped by their native language.
-
Gut microbes linked to fatty diet drive tumour growth Nature (IF 64.8) Pub Date : 2024-05-16
Scientists know there is a link between obesity and some cancers. A study in mice and people suggests why that might be.
-
Daily briefing: How AI could help mathematicians achieve ‘moments of divine inspiration’ Nature (IF 64.8) Pub Date : 2024-05-15
Mathematical conjectures could be the ideal testing ground for AI-assisted discovery. Plus, why humans are so good at running and how to kill ‘zombie’ cells that make us age.
-
Topological polarons in halide perovskites Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-17 Jon Lafuente-Bartolome, Chao Lian, Feliciano Giustino
Halide perovskites emerged as a revolutionary family of high-quality semiconductors for solar energy harvesting and energy-efficient lighting. There is mounting evidence that the exceptional optoelectronic properties of these materials could stem from unconventional electron–phonon couplings, and it has been suggested that the formation of polarons and self-trapped excitons could be key to understanding
-
Screening p -hackers: Dissemination noise as bait Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-17 Federico Echenique, Kevin He
We show that adding noise before publishing data effectively screens p -hacked findings: spurious explanations produced by fitting many statistical models (data mining). Noise creates “baits” that affect two types of researchers differently. Uninformed p -hackers, who are fully ignorant of the true mechanism and engage in data mining, often fall for baits. Informed researchers, who start with an ex
-
An encompassed representation of timescale hierarchies in first-order reaction network Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-17 Yutaka Nagahata, Masato Kobayashi, Mikito Toda, Satoshi Maeda, Tetsuya Taketsugu, Tamiki Komatsuzaki
Complex networks are pervasive in various fields such as chemistry, biology, and sociology. In chemistry, first-order reaction networks are represented by a set of first-order differential equations, which can be constructed from the underlying energy landscape. However, as the number of nodes increases, it becomes more challenging to understand complex kinetics across different timescales. Hence,
-
Productive scientists are associated with lower disruption in scientific publishing Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-17 Heyang Li, Claudio J. Tessone, An Zeng
While scientific researchers often aim for high productivity, prioritizing the quantity of publications may come at the cost of time and effort dedicated to individual research. It is thus important to examine the relationship between productivity and disruption for individual researchers. Here, we show that with the increase in the number of published papers, the average citation per paper will be
-
Establishing a biochemical understanding of the initiation of chromosome replication in bacteria Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-17 Bruce Stillman
In the mid-1950s, Arthur Kornberg elucidated the enzymatic synthesis of DNA by DNA polymerase, for which he was recognized with the 1959 Nobel Prize in Physiology or Medicine. He then identified many of the proteins that cooperate with DNA polymerase to replicate duplex DNA of small bacteriophages. However, one major unanswered problem was understanding the mechanism and control of the initiation of
-
Interferon signaling in the nasal epithelium distinguishes among lethal and common cold coronaviruses and mediates viral clearance Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-05-17 Clayton J. Otter, David M. Renner, Alejandra Fausto, Li Hui Tan, Noam A. Cohen, Susan R. Weiss
All respiratory viruses establish primary infections in the nasal epithelium, where efficient innate immune induction may prevent dissemination to the lower airway and thus minimize pathogenesis. Human coronaviruses (HCoVs) cause a range of pathologies, but the host and viral determinants of disease during common cold versus lethal HCoV infections are poorly understood. We model the initial site of
-
Enhancing PV power forecasting with deep learning and optimizing solar PV project performance with economic viability: A multi-case analysis of 10 MW Masdar project in UAE Energy Convers. Manag. (IF 10.4) Pub Date : 2024-05-17 Muhammad Faizan Tahir, Anthony Tzes, Muhammad Zain Yousaf
Renewable energy systems, particularly solar PV, are increasingly essential in addressing environmental and cost concerns associated with conventional energy sources However, accurately predicting PV generation power remains challenging due to its stochastic and volatile nature, coupled with the task of designing an optimal renewable energy system that balances efficiency and cost-effectiveness. This
-
CHESTER: Experimental prototype of a compressed heat energy storage and management system for energy from renewable sources Energy Convers. Manag. (IF 10.4) Pub Date : 2024-05-17 K. Theologou, M. Johnson, J. Tombrink, José L. Corrales Ciganda, Felipe T. Trebilcock, K. Couvreur, R. Tassenoy, S. Lecompte
The increasing share of renewable energies in the electricity grid requires storage technologies to balance energy supply and demand. Thermally integrated pumped thermal energy storage systems are considered a promising technology for medium to large-scale storage applications. Among these, compressed thermal energy storage in particular has been identified in numerous theoretical studies as a promising
-
Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines Nature (IF 64.8) Pub Date : 2024-05-15 Chieh-Yu Liang, Saravanan Raju, Zhuoming Liu, Yuhao Li, Guha Asthagiri Arunkumar, James Brett Case, Suzanne M. Scheaffer, Seth J. Zost, Cory M. Acreman, Matthew Gagne, Shayne F. Andrew, Deborah Carolina Carvalho dos Anjos, Kathryn E. Foulds, Jason S. McLellan, James E. Crowe, Daniel C. Douek, Sean P. J. Whelan, Sayda M. Elbashir, Darin K. Edwards, Michael S. Diamond
Immune imprinting is a phenomenon in which prior antigenic experiences influence responses to subsequent infection or vaccination1,2. The effects of immune imprinting on serum antibody responses after boosting with variant-matched SARS-CoV-2 vaccines remain uncertain. Here, we characterized the serum antibody responses after mRNA vaccine boosting of mice and human clinical trial participants. In mice
-
Organoids merge to model the blood–brain barrier Nature (IF 64.8) Pub Date : 2024-05-15
Combining a brain organoid with a blood-vessel organoid yields a system similar to a protective mesh in the brain.
-
Controlled failure: The building designed to limit catastrophe Nature (IF 64.8) Pub Date : 2024-05-15
New design - inspired by lizard tails - could save lives by isolating collapsing sections of damaged buildings
-
Evolution of a novel adrenal cell type that promotes parental care Nature (IF 64.8) Pub Date : 2024-05-15 Natalie Niepoth, Jennifer R. Merritt, Michelle Uminski, Emily Lei, Victoria S. Esquibies, Ina B. Bando, Kimberly Hernandez, Christoph Gebhardt, Sarah A. Wacker, Stefano Lutzu, Asmita Poudel, Kiran K. Soma, Stephanie Rudolph, Andres Bendesky
-
Suppressed thermal transport in silicon nanoribbons by inhomogeneous strain Nature (IF 64.8) Pub Date : 2024-05-15 Lin Yang, Shengying Yue, Yi Tao, Shuo Qiao, Hang Li, Zhaohe Dai, Bai Song, Yunfei Chen, Jinlong Du, Deyu Li, Peng Gao
-
The rise of baobab trees in Madagascar Nature (IF 64.8) Pub Date : 2024-05-15 Jun-Nan Wan, Sheng-Wei Wang, Andrew R. Leitch, Ilia J. Leitch, Jian-Bo Jian, Zhang-Yan Wu, Hai-Ping Xin, Mijoro Rakotoarinivo, Guy Eric Onjalalaina, Robert Wahiti Gituru, Can Dai, Geoffrey Mwachala, Ming-Zhou Bai, Chen-Xi Zhao, Hong-Qi Wang, Sheng-Lan Du, Neng Wei, Guang-Wan Hu, Si-Chong Chen, Xiao-Ya Chen, Tao Wan, Qing-Feng Wang
-
Arresting failure propagation in buildings through collapse isolation Nature (IF 64.8) Pub Date : 2024-05-15 Nirvan Makoond, Andri Setiawan, Manuel Buitrago, Jose M. Adam
-
Dispersion-assisted high-dimensional photodetector Nature (IF 64.8) Pub Date : 2024-05-15 Yandong Fan, Weian Huang, Fei Zhu, Xingsi Liu, Chunqi Jin, Chenzi Guo, Yang An, Yuri Kivshar, Cheng-Wei Qiu, Wei Li
-
GLP-1-directed NMDA receptor antagonism for obesity treatment Nature (IF 64.8) Pub Date : 2024-05-15 Jonas Petersen, Mette Q. Ludwig, Vaida Juozaityte, Pablo Ranea-Robles, Charlotte Svendsen, Eunsang Hwang, Amalie W. Kristensen, Nicole Fadahunsi, Jens Lund, Alberte W. Breum, Cecilie V. Mathiesen, Luisa Sachs, Roger Moreno-Justicia, Rebecca Rohlfs, James C. Ford, Jonathan D. Douros, Brian Finan, Bryan Portillo, Kyle Grose, Jacob E. Petersen, Mette Trauelsen, Annette Feuchtinger, Richard D. DiMarchi
-
Photocatalytic doping of organic semiconductors Nature (IF 64.8) Pub Date : 2024-05-15 Wenlong Jin, Chi-Yuan Yang, Riccardo Pau, Qingqing Wang, Eelco K. Tekelenburg, Han-Yan Wu, Ziang Wu, Sang Young Jeong, Federico Pitzalis, Tiefeng Liu, Qiao He, Qifan Li, Jun-Da Huang, Renee Kroon, Martin Heeney, Han Young Woo, Andrea Mura, Alessandro Motta, Antonio Facchetti, Mats Fahlman, Maria Antonietta Loi, Simone Fabiano
-
The temperature sensor TWA1 is required for thermotolerance in Arabidopsis Nature (IF 64.8) Pub Date : 2024-05-15 Lisa Bohn, Jin Huang, Susan Weidig, Zhenyu Yang, Christoph Heidersberger, Bernard Genty, Pascal Falter-Braun, Alexander Christmann, Erwin Grill
-
Temporal multiplexing of perception and memory codes in IT cortex Nature (IF 64.8) Pub Date : 2024-05-15 Liang She, Marcus K. Benna, Yuelin Shi, Stefano Fusi, Doris Y. Tsao
-
Superconducting diode effect and interference patterns in kagome CsV3Sb5 Nature (IF 64.8) Pub Date : 2024-05-15 Tian Le, Zhiming Pan, Zhuokai Xu, Jinjin Liu, Jialu Wang, Zhefeng Lou, Xiaohui Yang, Zhiwei Wang, Yugui Yao, Congjun Wu, Xiao Lin
-
Physiological temperature drives TRPM4 ligand recognition and gating Nature (IF 64.8) Pub Date : 2024-05-15 Jinhong Hu, Sung Jin Park, Tyler Walter, Ian J. Orozco, Garrett O‘Dea, Xinyu Ye, Juan Du, Wei Lü
-
Entanglement of nanophotonic quantum memory nodes in a telecom network Nature (IF 64.8) Pub Date : 2024-05-15 C. M. Knaut, A. Suleymanzade, Y.-C. Wei, D. R. Assumpcao, P.-J. Stas, Y. Q. Huan, B. Machielse, E. N. Knall, M. Sutula, G. Baranes, N. Sinclair, C. De-Eknamkul, D. S. Levonian, M. K. Bhaskar, H. Park, M. Lončar, M. D. Lukin
-
Engineered CD47 protects T cells for enhanced antitumour immunity Nature (IF 64.8) Pub Date : 2024-05-15 Sean A. Yamada-Hunter, Johanna Theruvath, Brianna J. McIntosh, Katherine A. Freitas, Frank Lin, Molly T. Radosevich, Amaury Leruste, Shaurya Dhingra, Naiara Martinez-Velez, Peng Xu, Jing Huang, Alberto Delaidelli, Moksha H. Desai, Zinaida Good, Roel Polak, Audre May, Louai Labanieh, Jeremy Bjelajac, Tara Murty, Zach Ehlinger, Christopher W. Mount, Yiyun Chen, Sabine Heitzeneder, Kristopher D. Marjon
-
Wavefunction matching for solving quantum many-body problems Nature (IF 64.8) Pub Date : 2024-05-15 Serdar Elhatisari, Lukas Bovermann, Yuan-Zhuo Ma, Evgeny Epelbaum, Dillon Frame, Fabian Hildenbrand, Myungkuk Kim, Youngman Kim, Hermann Krebs, Timo A. Lähde, Dean Lee, Ning Li, Bing-Nan Lu, Ulf-G. Meißner, Gautam Rupak, Shihang Shen, Young-Ho Song, Gianluca Stellin
-
One-third of Southern Ocean productivity is supported by dust deposition Nature (IF 64.8) Pub Date : 2024-05-15 Jakob Weis, Zanna Chase, Christina Schallenberg, Peter G. Strutton, Andrew R. Bowie, Sonya L. Fiddes
-
Decoding the interplay between genetic and non-genetic drivers of metastasis Nature (IF 64.8) Pub Date : 2024-05-15 Panagiotis Karras, James R. M. Black, Nicholas McGranahan, Jean-Christophe Marine
-
A renewably sourced, circular photopolymer resin for additive manufacturing Nature (IF 64.8) Pub Date : 2024-05-15 Thiago O. Machado, Connor J. Stubbs, Viviane Chiaradia, Maher A. Alraddadi, Arianna Brandolese, Joshua C. Worch, Andrew P. Dove
-
Volatile working memory representations crystallize with practice Nature (IF 64.8) Pub Date : 2024-05-15 Arash Bellafard, Ghazal Namvar, Jonathan C. Kao, Alipasha Vaziri, Peyman Golshani
-
Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice Nature (IF 64.8) Pub Date : 2024-05-15 Gang Wang, Xi Chen, Chengzhi Yu, Xiaobao Shi, Wenxian Lan, Chaofeng Gao, Jun Yang, Huiling Dai, Xiaowei Zhang, Huili Zhang, Boyu Zhao, Qi Xie, Nan Yu, Zuhua He, Yu Zhang, Ertao Wang
-
Dimerization and antidepressant recognition at noradrenaline transporter Nature (IF 64.8) Pub Date : 2024-05-15 Heng Zhang, Yu-Ling Yin, Antao Dai, Tianwei Zhang, Chao Zhang, Canrong Wu, Wen Hu, Xinheng He, Benxun Pan, Sanshan Jin, Qingning Yuan, Ming-Wei Wang, Dehua Yang, H. Eric Xu, Yi Jiang
-
Creation of memory–memory entanglement in a metropolitan quantum network Nature (IF 64.8) Pub Date : 2024-05-15 Jian-Long Liu, Xi-Yu Luo, Yong Yu, Chao-Yang Wang, Bin Wang, Yi Hu, Jun Li, Ming-Yang Zheng, Bo Yao, Zi Yan, Da Teng, Jin-Wei Jiang, Xiao-Bing Liu, Xiu-Ping Xie, Jun Zhang, Qing-He Mao, Xiao Jiang, Qiang Zhang, Xiao-Hui Bao, Jian-Wei Pan
-
Dual-action obesity drug rewires brain circuits for appetite Nature (IF 64.8) Pub Date : 2024-05-15 Tyler M. Cook, Darleen Sandoval
Two-in-one drug better than GLP-1 agonist alone at inducing weight loss.
-
Strategic links save buildings from total collapse Nature (IF 64.8) Pub Date : 2024-05-15 Sarah L. Orton
Design strategy for preventing failure propagation in buildings.
-
‘Quantum internet’ demonstration in cities is most advanced yet Nature (IF 64.8) Pub Date : 2024-05-15
Experiments generate quantum entanglement over optical fibres across three real cities, marking progress towards networks that could have revolutionary applications.
-
Experimental obesity drug packs double punch to reduce weight Nature (IF 64.8) Pub Date : 2024-05-15
Test of weight-loss candidate in mice shows that there is still room for improvement in a burgeoning field.
-
Parental-care puzzle in mice solved by thinking outside the brain Nature (IF 64.8) Pub Date : 2024-05-15 Jessica Tollkuhn
Previously unknown cell type found in mice that share parental care.
-
Lizard-inspired building design could save lives Nature (IF 64.8) Pub Date : 2024-05-15
Hear the biggest stories from the world of science | 15 May 2024
-
mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies Science (IF 56.9) Pub Date : 2024-05-16 Zhenfei Xie, Ying-Cing Lin, Jon M. Steichen, Gabriel Ozorowski, Sven Kratochvil, Rashmi Ray, Jonathan L. Torres, Alessia Liguori, Oleksandr Kalyuzhniy, Xuesong Wang, John E. Warner, Stephanie R. Weldon, Gordon A. Dale, Kathrin H. Kirsch, Usha Nair, Sabyasachi Baboo, Erik Georgeson, Yumiko Adachi, Michael Kubitz, Abigail M. Jackson, Sara T. Richey, Reid M. Volk, Jeong Hyun Lee, Jolene K. Diedrich, Thavaleak
Germline-targeting (GT) HIV vaccine strategies are predicated on deriving broadly neutralizing antibodies (bnAbs) through multiple boost immunogens. However, as the recruitment of memory B cells (MBCs) to germinal centers (GCs) is inefficient and may be derailed by serum antibody–induced epitope masking, driving further B cell receptor (BCR) modification in GC-experienced B cells after boosting poses
-
An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wide gene delivery Science (IF 56.9) Pub Date : 2024-05-16 Qin Huang, Ken Y. Chan, Jason Wu, Nuria R. Botticello-Romero, Qingxia Zheng, Shan Lou, Casey Keyes, Alexander Svanbergsson, Jencilin Johnston, Allan Mills, Chin-Yen Lin, Pamela P. Brauer, Gabrielle Clouse, Simon Pacouret, John W. Harvey, Thomas Beddow, Jenna K. Hurley, Isabelle G. Tobey, Megan Powell, Albert T. Chen, Andrew J. Barry, Fatma-Elzahraa Eid, Yujia A. Chan, Benjamin E. Deverman
Developing vehicles that efficiently deliver genes throughout the human central nervous system (CNS) will broaden the range of treatable genetic diseases. We engineered an adeno-associated virus (AAV) capsid, BI-hTFR1, that binds human transferrin receptor (TfR1), a protein expressed on the blood-brain barrier (BBB). BI-hTFR1 was actively transported across human brain endothelial cells and, relative
-
Diamond-lattice photonic crystals assembled from DNA origami Science (IF 56.9) Pub Date : 2024-05-16 Gregor Posnjak, Xin Yin, Paul Butler, Oliver Bienek, Mihir Dass, Seungwoo Lee, Ian D. Sharp, Tim Liedl
Colloidal self-assembly allows rational design of structures on the micrometer and submicrometer scale. One architecture that can generate complete three-dimensional photonic bandgaps is the diamond cubic lattice, which has remained difficult to realize at length scales comparable with the wavelength of visible or ultraviolet light. In this work, we demonstrate three-dimensional photonic crystals self-assembled
-
Metabolic loads and the costs of metazoan reproduction Science (IF 56.9) Pub Date : 2024-05-16 Samuel C. Ginther, Hayley Cameron, Craig R. White, Dustin J. Marshall
Reproduction includes two energy investments—the energy in the offspring and the energy expended to make them. The former is well understood, whereas the latter is unquantified but often assumed to be small. Without understanding both investments, the true energy costs of reproduction are unknown. We present a framework for estimating the total energy costs of reproduction by combining data on the
-
AlphaFold2 structures guide prospective ligand discovery Science (IF 56.9) Pub Date : 2024-05-16 Jiankun Lyu, Nicholas Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish K. Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey DiBerto, Kuglae Kim, Isabella S. Glenn, Tia A. Tummino, Sijie Huang, John J. Irwin, Olga O. Tarkhanova, Yurii Moroz, Georgios Skiniotis, Andrew C. Kruse, Brian K. Shoichet, Bryan L. Roth
AlphaFold2 (AF2) models have had wide impact, but they have had mixed success in retrospective ligand recognition. We prospectively docked large libraries against unrefined AF2 models of the σ2 and 5-HT2A receptors, testing hundreds of new molecules and comparing results to docking against the experimental structures. Hit rates were high and similar for the experimental and the AF2 structures, as were
-
Global band convergence design for high-performance thermoelectric power generation in Zintls Science (IF 56.9) Pub Date : 2024-05-16 Xin Shi, Shaowei Song, Guanhui Gao, Zhifeng Ren
Electronic band convergence can have a beneficial impact on thermoelectric performance, but finding the right band-converged compositions is still time-consuming. We propose a method for designing a series of compositions with simultaneous band convergence in the high-entropy Yb x Ca 1− x Mg y Zn 2− y Sb 2 material by zeroing the weighted sum of crystal-field splitting energies of the parent compounds
-
Tool use increases mechanical foraging success and tooth health in southern sea otters ( Enhydra lutris nereis ) Science (IF 56.9) Pub Date : 2024-05-16 Chris J. Law, M. Tim Tinker, Jessica A. Fujii, Teri Nicholson, Michelle Staedler, Joseph A. Tomoleoni, Colleen Young, Rita S. Mehta
Although tool use may enhance resource utilization, its fitness benefits are difficult to measure. By examining longitudinal data from 196 radio-tagged southern sea otters ( Enhydra lutris nereis ), we found that tool-using individuals, particularly females, gained access to larger and/or harder-shelled prey. These mechanical advantages translated to reduced tooth damage during food processing. We
-
Delocalized, asynchronous, closed-loop discovery of organic laser emitters Science (IF 56.9) Pub Date : 2024-05-16 Felix Strieth-Kalthoff, Han Hao, Vandana Rathore, Joshua Derasp, Théophile Gaudin, Nicholas H. Angello, Martin Seifrid, Ekaterina Trushina, Mason Guy, Junliang Liu, Xun Tang, Masashi Mamada, Wesley Wang, Tuul Tsagaantsooj, Cyrille Lavigne, Robert Pollice, Tony C. Wu, Kazuhiro Hotta, Leticia Bodo, Shangyu Li, Mohammad Haddadnia, Agnieszka Wołos, Rafał Roszak, Cher Tian Ser, Carlota Bozal-Ginesta, Riley
Contemporary materials discovery requires intricate sequences of synthesis, formulation, and characterization that often span multiple locations with specialized expertise or instrumentation. To accelerate these workflows, we present a cloud-based strategy that enabled delocalized and asynchronous design-make-test-analyze cycles. We showcased this approach through the exploration of molecular gain
-
DNA damage induces p53-independent apoptosis through ribosome stalling Science (IF 56.9) Pub Date : 2024-05-16 Nicolaas J. Boon, Rafaela A. Oliveira, Pierré-René Körner, Adva Kochavi, Sander Mertens, Yuval Malka, Rhianne Voogd, Suzanne E. M. van der Horst, Maarten A. Huismans, Lidwien P. Smabers, Jonne M. Draper, Lodewyk F. A. Wessels, Peter Haahr, Jeanine M. L. Roodhart, Ton N. M. Schumacher, Hugo J. Snippert, Reuven Agami, Thijn R. Brummelkamp
In response to excessive DNA damage, human cells can activate p53 to induce apoptosis. Cells lacking p53 can still undergo apoptosis upon DNA damage, yet the responsible pathways are unknown. We observed that p53-independent apoptosis in response to DNA damage coincided with translation inhibition, which was characterized by ribosome stalling on rare leucine-encoding UUA codons and globally curtailed