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The Legacy of Rita Levi-Montalcini: From Nerve Growth Factor to Neuroinflammation.
The Neuroscientist ( IF 3.5 ) Pub Date : 2019-01-30 , DOI: 10.1177/1073858419827273
Domenico Chirchiglia 1 , Pasquale Chirchiglia 1 , Dorotea Pugliese 1 , Rosa Marotta 2
Affiliation  

Rita Levi-Montalcini was an extraordinary personality and with her profession she made a tremendous contribution to humanity. Doctor, Nobel laureate for medicine, neuroscientist, she contributed, thanks to her research, to improve the knowledge of the nervous system. She discovered the nerve growth factor, which is applied in various fields of neurology, concerning neurodegenerative diseases. She also studied, in relatively newer years, the mechanisms of neuroinflammation. This last is a research that has been developing in recent years and is based on the predominantly anti-inflammatory properties of endogenous substances that able to act not only on diseases of the nerves, neuropathies, on the nerve roots, and radiculopathies but also on migraine and other non-neurological diseases. Her long life was full of positive and negative events. Born in a Jewish family, she lived her life as a young woman through war, Nazi deportations, and the Holocaust. Despite the difficulties, she found time to do research in the medical field, organizing research laboratories with other scholars. She had a difficult life, interspread with pain, destruction, extermination of human beings but also rewarded by scientific discoveries. A "small" woman but a great neuroscientist.

中文翻译:

丽塔·莱维·蒙塔奇尼(Rita Levi-Montalcini)的遗产:从神经生长因子到神经炎症。

丽塔·列维·蒙塔奇尼(Rita Levi-Montalcini)具有非凡的个性,她的职业生涯为人类做出了巨大贡献。医生,诺贝尔医学奖获得者,神经科学家,由于她的研究,她为改善神经系统知识做出了贡献。她发现了神经生长因子,该神经生长因子被应用于神经学的各个领域,涉及神经退行性疾病。在相对较新的几年中,她还研究了神经炎症的机制。这是最近几年进行的一项研究,其研究结果基于内源性物质的主要抗炎特性,这些内源性物质不仅能对神经疾病,神经病,神经根和神经根病起作用,而且对偏头痛也能起作用和其他非神经疾病。她的一生充满了积极和消极的事件。她出生于一个犹太家庭,年轻时曾通过战争,纳粹驱逐和大屠杀过日子。尽管困难重重,她还是抽出了时间从事医学领域的研究,与其他学者一起组建了研究实验室。她生活艰难,充满痛苦,破坏,灭绝人类,但也得到了科学发现的回报。一个“小”女人,但是一个伟大的神经科学家。
更新日期:2020-02-04
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