当前位置: X-MOL 学术J. Am. Acad. Dermatol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Tissue-sparing properties of Mohs micrographic surgery for infiltrative basal cell carcinoma
Journal of the American Academy of Dermatology ( IF 12.8 ) Pub Date : 2019-01-31 , DOI: 10.1016/j.jaad.2019.01.057
Marloes S. van Kester , Jelle J. Goeman , Roel E. Genders

Background

Mohs micrographic surgery (MMS) should lead to tissue sparing of healthy skin compared with standard surgical excision because smaller surgical margins are used.

Objective

To quantify the tissue-sparing properties of MMS in primary basal cell carcinoma (BCC) with an infiltrative growth pattern.

Methods

A prospective study including 256 primary BCCs with an infiltrative growth pattern was performed. Tumor sizes were measured in 2 perpendicular directions. Surface defect areas after MMS were measured. The suspected defect surface area with standard excision using a 5-mm margin was calculated. The primary outcome of this study was the size of the defect surface area spared with MMS compared with the calculated defect surface area with a standard excision.

Results

The median tumor size was 71 mm2, and the median defect size after MMS was 154 mm2. The median defect size calculated for standard surgical excision was 298 mm2. We have shown that MMS of BCC with an infiltrative growth pattern had a 46.4% tissue-sparing effect when compared with standard surgical excision (95% confidence interval, 43.4%-49.1%; P value < .001).

Limitations

Single-center study design. Lack of a randomized control group for ethical reasons.

Conclusion

A rate of tissue sparing of 46% can be reached by using MMS for primary BCC with an infiltrative growth pattern.



中文翻译:

Mohs显微外科手术治疗浸润性基底细胞癌的组织保留特性

背景

与标准手术切除相比,莫氏显微外科手术(MMS)可以节省健康皮肤的组织,因为使用的手术切缘较小。

客观的

若要量化具有浸润性生长模式的原发性基底细胞癌(BCC)中MMS的保留组织特性。

方法

进行了一项前瞻性研究,包括256个具有浸润性生长模式的原发性BCC。在两个垂直方向上测量肿瘤大小。测量了MMS之后的表面缺陷区域。通过标准切除(使用5 mm的余量)计算出可疑的缺陷表面积。这项研究的主要结果是与标准切除术相比,MMS保留的缺损表面积的大小与计算出的缺损表面积相比。

结果

中位肿瘤大小为71 mm 2,MMS后中位缺陷大小为154 mm 2。计算出的标准手术切除的中位缺损大小为298 mm 2。我们已经显示,具有浸润性生长模式的BCC的MMS与标准手术切除相比具有46.4%的组织保留效应(95%置信区间,43.4%-49.1%;P值<.001)。

局限性

单中心研究设计。出于道德原因缺乏随机对照组。

结论

通过将MMS用于具有浸润性生长模式的原发性BCC,可以达到46%的组织保留率。

更新日期:2019-01-31
down
wechat
bug