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Modulation of caspase-3 gene expression and protective effects of garlic and spirulina against CNS neurotoxicity induced by lead exposure in male rats.
NeuroToxicology ( IF 3.4 ) Pub Date : 2019-01-28 , DOI: 10.1016/j.neuro.2019.01.006
Mona K Galal 1 , Ebtihal M M Elleithy 2 , Mohamed I Abdrabou 2 , Noha A E Yasin 2 , Youssef M Shaheen 2
Affiliation  

Lead (Pb) is a ubiquitous environmental and industrial pollutant with worldwide health problems. The present study was designed to investigate the neurotoxic effects of Pb in albino rats and to evaluate the ameliorative role of garlic as well as Spirulina maxima against such toxic effects. Forty adult male rats were used in this investigation (10 rats/group). Group I: served as control, Group II: rats received lead acetate (100 mg/kg), Group III: rats received both lead acetate (100 mg/kg) and garlic (600 mg/kg) and Group IV: rats received both lead acetate (100 mg/kg) and spirulina (500 mg/kg) daily by oral gavage for one month. Exposure to Pb acetate adversely affected the measured acetyl cholinesterase enzyme activity, oxidative stress and lipid peroxidation parameters as well as caspase-3 gene expression in brain tissue (cerebrum and cerebellum). Light and electron microscopical examination of the cerebrum and cerebellum showed various lesions after exposure to Pb which were confirmed by immunohistochemistry. On the other hand, administration of garlic and spirulina concomitantly with lead acetate ameliorated most of the undesirable effects. It could be concluded that, the adverse effects induced by lead acetate, were markedly ameliorated by co-treatment with S. maxima more than garlic.

中文翻译:

caspase-3基因表达的调控以及大蒜和螺旋藻对铅暴露引起的中枢神经系统神经毒性的保护作用。

铅(Pb)是一种普遍存在的环境和工业污染物,具有全球性的健康问题。本研究旨在研究铅对白化病大鼠的神经毒性作用,并评估大蒜以及最大螺旋藻对此类毒性作用的改善作用。在该研究中使用了40只成年雄性大鼠(每组10只大鼠)。第一组:作为对照组,第二组:大鼠接受乙酸铅(100 mg / kg),第三组:大鼠接受乙酸铅(100 mg / kg)和大蒜(600 mg / kg),第四组:大鼠接受两种每天通过管饲法服用乙酸铅(100 mg / kg)和螺旋藻(500 mg / kg),持续1个月。暴露于乙酸铅对测量的乙酰胆碱酯酶活性有不利影响,氧化应激和脂质过氧化参数以及脑组织(大脑和小脑)中的caspase-3基因表达。大脑和小脑的光镜和电子显微镜检查显示,暴露于Pb后有多种病变,这是通过免疫组织化学证实的。另一方面,大蒜和螺旋藻与乙酸铅的同时给药可改善大多数不良作用。可以得出结论,与大蒜相比,与最大链球菌共处理可明显减轻乙酸铅引起的不利影响。大蒜和螺旋藻与醋酸铅同时给药可改善大多数不良作用。可以得出结论,与大蒜相比,与最大链球菌共处理可明显减轻乙酸铅引起的不利影响。大蒜和螺旋藻与醋酸铅同时给药可改善大多数不良作用。可以得出结论,与大蒜相比,与最大链球菌共处理可明显减轻乙酸铅引起的不利影响。
更新日期:2019-01-28
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