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Extra-adrenal glucocorticoid synthesis at epithelial barriers.
Genes and Immunity ( IF 5.0 ) Pub Date : 2019-01-29 , DOI: 10.1038/s41435-019-0058-z Truong San Phan 1 , Verena M Merk 1 , Thomas Brunner 1
Genes and Immunity ( IF 5.0 ) Pub Date : 2019-01-29 , DOI: 10.1038/s41435-019-0058-z Truong San Phan 1 , Verena M Merk 1 , Thomas Brunner 1
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Epithelial barriers play an important role in the exchange of nutrients, gases, and other signals between our body and the outside world. However, they protect it also from invasion by potential pathogens. Defective epithelial barriers and associated overshooting immune responses are the basis of many different inflammatory disorders of the skin, the lung, and the intestinal mucosa. The anti-inflammatory activity of glucocorticoids has been efficiently used for the treatment of these diseases. Interestingly, epithelia in these tissues are also a rich source of endogenous glucocorticoids, suggesting that local glucocorticoid synthesis is part of a tissue-specific regulatory circuit. In this review, we summarize current knowledge about the extra-adrenal glucocorticoid synthesis at the epithelial barriers of the intestine, lung and the skin, and discuss their relevance in the pathogenesis of inflammatory diseases and as therapeutic targets.
中文翻译：
上皮屏障上的肾上腺外糖皮质激素合成。
上皮屏障在人体与外界之间的营养，气体和其他信号交换中起着重要作用。但是，它们还可以保护其免受潜在病原体的侵袭。缺陷的上皮屏障和相关的过度免疫反应是皮肤，肺和肠粘膜许多不同炎症性疾病的基础。糖皮质激素的抗炎活性已被有效地用于治疗这些疾病。有趣的是，这些组织中的上皮细胞也是内源性糖皮质激素的丰富来源，这表明局部糖皮质激素合成是组织特异性调节回路的一部分。在这篇综述中，我们总结了当前有关肠，肺和皮肤上皮屏障的肾上腺糖皮质激素合成的知识，
更新日期：2019-01-29
中文翻译：
上皮屏障上的肾上腺外糖皮质激素合成。
上皮屏障在人体与外界之间的营养，气体和其他信号交换中起着重要作用。但是，它们还可以保护其免受潜在病原体的侵袭。缺陷的上皮屏障和相关的过度免疫反应是皮肤，肺和肠粘膜许多不同炎症性疾病的基础。糖皮质激素的抗炎活性已被有效地用于治疗这些疾病。有趣的是，这些组织中的上皮细胞也是内源性糖皮质激素的丰富来源，这表明局部糖皮质激素合成是组织特异性调节回路的一部分。在这篇综述中，我们总结了当前有关肠，肺和皮肤上皮屏障的肾上腺糖皮质激素合成的知识，
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