We sought datasets with granular age distributions of rotavirus-positive disease presentations among children <5 years of age, before the introduction of rotavirus vaccines. We identified 117 datasets and fit parametric age distributions to each country dataset and mortality stratum. We calculated the median age and the cumulative proportion of rotavirus gastroenteritis events expected to occur at ages between birth and 5.0 years. The median age of rotavirus-positive hospital admissions was 38 weeks (interquartile range [IQR], 25-58 weeks) in countries with very high child mortality and 65 weeks (IQR, 40-107 weeks) in countries with very low or low child mortality. In countries with very high child mortality, 69% of rotavirus-positive admissions in children <5 years of age were in the first year of life, with 3% by 10 weeks, 8% by 15 weeks, and 27% by 26 weeks. This information is critical for assessing the potential benefits of alternative rotavirus vaccination schedules in different countries and for monitoring program impact.

中文翻译：

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轮状病毒疫苗接种前5岁以下儿童轮状病毒疾病年龄分布的全球综述。

在引入轮状病毒疫苗之前，我们寻找了年龄小于5岁的儿童中轮状病毒阳性疾病呈报的年龄分布的数据集。我们确定了117个数据集，并将参数化年龄分布与每个国家的数据集和死亡率层次进行了拟合。我们计算了轮状病毒胃肠炎事件的中位年龄和累积比例，这些事件预期发生在出生至5.0岁之间。在儿童死亡率很高的国家中，轮状病毒阳性住院患者的中位年龄为38周（四分位间距[IQR]，为25-58周），在儿童非常低或很低的国家中，年龄为65周（IQR，为40-107周）。死亡。在儿童死亡率很高的国家/地区，年龄小于5岁的儿童中轮状病毒阳性入院人数的69％处于出生后的第一年，其中10％时为3％，15周时时为8％，到26周时占27％。该信息对于评估不同国家的轮状病毒疫苗接种时间表的潜在利益以及监测计划的影响至关重要。