Persistence and clinical relevance of Zika virus in the male genital tract.,Nature Reviews Urology

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Persistence and clinical relevance of Zika virus in the male genital tract.
Nature Reviews Urology ( IF 12.1 ) Pub Date : 2019-04-01 , DOI: 10.1038/s41585-019-0149-7
Fábio A Kurscheidt ₁ , Cristiane S S Mesquita ₁ , Gabrielle M Z F Damke ₁ , Edilson Damke ₁ , Analine R B de A Carvalho ₁ , Tamy T Suehiro ₁ , Jorge J V Teixeira ₂ , Vânia R S da Silva ₁ , Raquel P Souza ₁ , Marcia E L Consolaro ₁

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Zika virus (ZIKV) is a re-emerging mosquito-transmitted flavivirus associated with congenital abnormalities in newborns and with Guillain-Barré syndrome in adults. The virus can also be sexually transmitted and can persist in the male genital tract. Studies evaluating the kinetics of ZIKV in seminal shedding of men who have been infected, as well as in animal and cellular models of infection, have shown that, in addition to the testis and epididymis, the prostate and seminal vesicles could also be involved in persistent ZIKV infection. Additionally, some studies have reported that men infected with ZIKV can present with genitourinary symptoms such as haematospermia, prostatitis, painful ejaculation, penile discharge, and oligospermia; however, little is known about the effect of ZIKV on fertility. Understanding the mechanisms that underlie persistent ZIKV infections in men is crucial to developing guidelines, effective vaccines, and therapies.

中文翻译：

寨卡病毒在男性生殖道中的持久性和临床相关性。

寨卡病毒 (ZIKV) 是一种重新出现的由蚊子传播的黄病毒，与新生儿先天性异常和成人格林-巴利综合征有关。该病毒也可以通过性传播，并可以在男性生殖道中持续存在。评估 ZIKV 在已感染男性精液脱落中的动力学以及在动物和细胞感染模型中的研究表明，除了睾丸和附睾外，前列腺和精囊也可能参与持续性感染。 ZIKV 感染。此外，一些研究报告称，感染 ZIKV 的男性会出现泌尿生殖系统症状，例如血精症、前列腺炎、射精痛、阴茎分泌物和少精症；然而，人们对 ZIKV 对生育能力的影响知之甚少。

更新日期：2019-05-16

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