Studies on hematopoietic stem cells have provided several critical insights in the biology of stem cells in general; as mature blood cells are generally short lived, stem cells are in fact required to guarantee, throughout the life of an organism, the replenishment of differentiated blood cells by the generation of multi-lineage progenitors and precursors committed to individual hematopoietic lineages. Similarly, acute myeloid leukemia has been considered as a model system to study cancer stem cells. This presentation illustrates some recent results obtained by our group with regard to both normal and leukemic stem cells.

中文翻译：

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正常和白血病干细胞

造血干细胞的研究总体上为干细胞生物学提供了一些重要的见解。由于成熟的血细胞通常寿命很短，实际上需要干细胞来保证在生物体的整个生命周期中，通过产生多谱系的祖细胞和用于单个造血谱系的前体来补充分化的血细胞。同样，急性髓性白血病已被视为研究癌症干细胞的模型系统。本演示文稿说明了我们小组最近在正常和白血病干细胞方面获得的一些结果。