Autophagy inhibition has been shown to sensitize tumor cells to cell death induced by tyrosine kinase inhibitors (TKIs). The remarkable responses obtained in seven patients with the combination of clarithromycin and TKIs support the hypothesis that the inhibition of autophagy may make chronic myeloid leukemia cells sensitive to killing by TKIs.

中文翻译：

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克拉霉素抑制自噬：增强 CML 干细胞对酪氨酸激酶抑制剂敏感性的新策略

自噬抑制已显示使肿瘤细胞对酪氨酸激酶抑制剂 (TKI) 诱导的细胞死亡敏感。在 7 名克拉霉素和 TKI 联合用药的患者中获得的显着反应支持了这样的假设，即抑制自噬可能使慢性髓性白血病细胞对 TKI 的杀伤敏感。