BDJ Open ( IF 2.5 ) Pub Date : 2017-02-10 , DOI: 10.1038/bdjopen.2017.2 Bogusława Orzechowska-Wylęgała 1 , Adam Wylęgała 2 , Michał Buliński 1 , Iwona Niedzielska 1 , Andrzej Madej 3
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Objectives/Aims:
The aim of this study was to investigate the microbial cultures collected in the years 2013–2014 at the craniomaxillofacial department and outpatient clinic to analyse optimisation of the treatment cost of the bacterial infections and present the results.
Design and setting:
We analysed 485 cultures from 263 patients, of which 77.28% consisted of Gram-positive bacteria. On the basis of the antibiotic efficacy, antibiotic price and the cost of entire treatment during hospitalisation, the most useful antimicrobial agents for the most common pathogens were selected.
Results:
The most frequently collected material was pus. The most common pathogens were found to be the Staphylococcus epidermidis (18%), Streptococcus mitis and Str. oralis (14%) and S. aureus (6.5%).
Discussion:
The most frequently isolated bacteria in other studies were the Streptococcus strain. Other authors showed that ceftriaxone is the most cost efficient agent. The use of postoperative antibiotic prophylaxis remains controversial.
Conclusion:
The results of this study suggest that the most useful antibiotics for therapy, from the perspective of the cost minimisation, were gentamycin, trimethoprim with sulfamethoxazole and vancomycin.
中文翻译：
颌面外科抗生素治疗的药物经济学分析
目标/目的：
本研究的目的是调查 2013-2014 年在颅颌面科和门诊收集的微生物培养物，以分析细菌感染治疗成本的优化并呈现结果。
设计与设置：
我们分析了来自 263 名患者的 485 份培养物，其中 77.28% 由革兰氏阳性菌组成。根据抗生素疗效、抗生素价格和住院期间的整个治疗费用，选择对最常见病原体最有用的抗菌药物。
结果：
最常收集的材料是脓液。发现最常见的病原体是表皮葡萄球菌（18%）、链球菌和链球菌。口腔杆菌(14%) 和金黄色葡萄球菌(6.5%)。
讨论：
在其他研究中最常分离的细菌是链球菌菌株。其他作者表明，头孢曲松是最具成本效益的药物。术后预防性抗生素的使用仍存在争议。
结论：
这项研究的结果表明，从成本最小化的角度来看，最有用的治疗抗生素是庆大霉素、复方磺胺甲恶唑和万古霉素。
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