Clinical study to monitor dentinal hypersensitivity with episodic use of a desensitising dentifrice,BDJ Open

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Clinical study to monitor dentinal hypersensitivity with episodic use of a desensitising dentifrice
BDJ Open ( IF 2.5 ) Pub Date : 2017-06-23 , DOI: 10.1038/bdjopen.2017.11
Stephen Mason ₁ , Rose Kingston ₂ , Lucy Shneyer ₃ , Máiréad Harding ₂

Affiliation

Objectives/Aims:

To evaluate continuous and episodic twice-daily usage regimens of a desensitising dentifrice containing 5% calcium sodium phosphosilicate (CSPS).

Materials and Methods:

In this exploratory, single-centre, randomised, examiner-blind study, subjects with dentinal hypersensitivity were randomised to continuous (24 weeks) use of a 5% CSPS-containing dentifrice or episodic use of the dentifrice comprising two 8-week treatment periods separated by 8 weeks′ use of a standard fluoride dentifrice. Sensitivity was assessed by tactile threshold (Yeaple probe) and evaporative (air) sensitivity (Schiff sensitivity score). Other measures included labelled magnitude scales to assess subjects′ responses to the evaporative stimulus, the Dentine Hypersensitivity Experience Questionnaire and a tooth sensitivity question.

Results:

Seventy-six subjects were randomised to continuous (n=38) or episodic (n=38) use. Small but statistically significant improvements from baseline in Schiff sensitivity scores were observed at weeks 8, 16 and 24 with both regimens (all P<0.05). Increases from baseline in tactile threshold were not statistically significant. No significant between-regimen difference was observed for any endpoint. No treatment-related adverse events were reported.

Discussion:

Dentifrice containing 5% CSPS improved dentinal hypersensitivity with both episodic and continuous twice-daily usage regimens over 24 weeks and was well tolerated.

Conclusion:

No performance differences were observed between the two usage regimens.

中文翻译：

使用脱敏洁牙剂监测牙本质过敏的临床研究

目标/目的：

评估含有 5% 磷硅酸钙钠 (CSPS) 的脱敏洁牙剂的连续和间歇性每日两次使用方案。

材料和方法：

在这项探索性、单中心、随机、检查者盲的研究中，牙本质过敏的受试者被随机分配到连续（24 周）使用含 5% CSPS 的洁牙剂或间歇使用洁齿剂，其中包括两个分开的 8 周治疗期使用标准含氟牙膏 8 周。通过触觉阈值（Yeaple 探针）和蒸发（空气）敏感性（Schiff 敏感性评分）评估敏感性。其他措施包括用于评估受试者对蒸发刺激反应的标记量表、牙本质过敏体验问卷和牙齿敏感性问题。

结果：

76 名受试者被随机分配至连续使用（n =38）或间歇使用（n =38）。在第 8 周、第 16 周和第 24 周，两种方案的 Schiff 敏感性评分均较基线有小幅但具有统计学意义的改善（均P <0.05）。触觉阈值从基线的增加没有统计学意义。对于任何终点，均未观察到显着的方案间差异。没有报告与治疗相关的不良事件。