Good syndrome is an immunodeficiency presenting with thymoma, hypogammaglobulinemia and almost absent B cells. To investigate the origin of the B-cell lymphopenia in these patients, we studied B cell differentiation in the bone marrow of Good syndrome patients. We found very low numbers of precursor B cells in bone marrow of Good syndrome patients and a differentiation arrest after the pro-B-cell stage; this is different from other agammaglobulinemia patients with a defect in pre B-cell receptor signaling.

中文翻译：

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Good综合征患者骨髓中的前体B细胞发育。

良好综合症是一种免疫缺陷，伴有胸腺瘤，低血球蛋白血症和几乎不存在的B细胞。为了调查这些患者中B细胞淋巴细胞减少症的起源，我们研究了Good综合征患者骨髓中B细胞的分化。我们发现Good综合征患者的骨髓中的前体B细胞数量非常少，并且在pro B细胞阶段后分化停止。这与其他前B细胞受体信号传导缺陷的丙种球蛋白血症患者不同。