This review focuses primarily on the beneficial effects for human health of exposure to ultraviolet radiation (UVR). UVR stimulates anti-inflammatory and immunosuppressive pathways in skin that modulate psoriasis, atopic dermatitis, and vitiligo; suppresses cutaneous lesions of graft-versus-host disease; and regulates some infection and vaccination outcomes. While polymorphic light eruption and the cutaneous photosensitivity of systemic lupus erythematosus are triggered by UVR, polymorphic light eruption also frequently benefits from UVR-induced immunomodulation. For systemic diseases such as multiple sclerosis, type 1 diabetes, asthma, schizophrenia, autism, and cardiovascular disease, any positive consequences of UVR exposure are more speculative, but could occur through the actions of UVR-induced regulatory cells and mediators, including 1,25-dihydroxy vitamin D3, interleukin-10, and nitric oxide. Reduced UVR exposure is a risk factor for the development of several inflammatory, allergic, and autoimmune conditions, including diseases initiated in early life. This suggests that UVR-induced molecules can regulate cell maturation in developing organs.

中文翻译：

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在人类疾病的调制中暴露于紫外线辐射。

这篇综述主要集中在紫外线辐射（UVR）对人体健康的有益影响上。UVR刺激皮肤中的抗炎和免疫抑制途径，这些途径可调节牛皮癣，特应性皮炎和白癜风。抑制移植物抗宿主病的皮肤病变；并调节一些感染和疫苗接种的结果。虽然多态性光疹和全身性红斑狼疮的皮肤光敏性是由UVR引发的，但多态性光疹也常常得益于UVR诱导的免疫调节。对于系统性疾病，例如多发性硬化症，1型糖尿病，哮喘，精神分裂症，自闭症和心血管疾病，暴露于UVR的任何积极后果更具推测性，但可能通过UVR诱导的调节细胞和介体的作用而发生，包括1，25-二羟基维生素D3，白介素10和一氧化氮。减少UVR暴露是多种炎症，变态反应和自身免疫疾病发展的危险因素，包括早年引发的疾病。这表明UVR诱导的分子可以调节发育器官中的细胞成熟。