Cardiovascular diseases exist across all developed countries. Biomarkers that can predict or diagnose diseases early in their pathogeneses can reduce their morbidity and mortality in afflicted individuals. microRNAs are small regulatory RNAs that modulate translation and have been identified as potential fluid-based biomarkers across numerous maladies. We describe the current state of cardiovascular disease biomarkers across a range of diseases, including myocardial infarction, acute coronary syndrome, myocarditis, hypertension, heart failure, heart transplantation, aortic stenosis, diabetic cardiomyopathy, atrial fibrillation, and sepsis. We present the current understanding of microRNAs as possible biomarkers in these categories and where their best opportunities exist to enter clinical practice.

中文翻译：

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microRNA 在心血管生物标志物这个拥挤的领域中的机会。


所有发达国家都存在心血管疾病。能够在疾病发病早期预测或诊断疾病的生物标志物可以降低患病个体的发病率和死亡率。 microRNA 是调节翻译的小调节 RNA，已被确定为多种疾病的潜在液体生物标志物。我们描述了一系列疾病的心血管疾病生物标志物的现状，包括心肌梗死、急性冠状动脉综合征、心肌炎、高血压、心力衰竭、心脏移植、主动脉瓣狭窄、糖尿病心肌病、心房颤动和脓毒症。我们介绍了目前对 microRNA 作为这些类别中可能的生物标志物的理解，以及它们进入临床实践的最佳机会。