Hippocampal abnormalities have been heavily implicated in the pathophysiology of schizophrenia. The dentate gyrus of the hippocampus was shown to manifest an immature molecular profile in schizophrenia subjects, as well as in various animal models of the disorder. In this position paper, we advance a hypothesis that this immature molecular profile is accompanied by an identifiable immature morphology of the dentate gyrus granule cell layer. We adduce evidence for arrested maturation of the dentate gyrus in the human schizophrenia-affected brain, as well as multiple rodent models of the disease. Implications of this neurohistopathological signature for current theory regarding the development of schizophrenia are discussed.

中文翻译：

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精神分裂症的齿状回未成熟。

海马异常与精神分裂症的病理生理密切相关。在精神分裂症患者以及该疾病的各种动物模型中，海马的齿状回显示出不成熟的分子特征。在这份立场文件中，我们提出了一个假说，即这种未成熟的分子轮廓伴随着齿状回颗粒细胞层的可识别的未成熟形态。我们为人类精神分裂症患者的大脑以及多种啮齿动物模型提供了齿状回被逮捕成熟的证据。讨论了这种神经组织病理学特征对当前有关精神分裂症发展的理论的意义。