A sensitive fluorescent chemical nanosensor for the detection of entacapone (EN) in pharmaceutical samples is introduced. EN is a nitrocatechol drug that functions as a selective and reversible inhibitor of catechol-O-methyl transferase and is widely prescribed in the treatment of Parkinson disease. Molecularly imprinting technology and graphene oxide quantum dots (GOQDs) were employed in designing the EN fluorescent nanosensor. GOQDs were embedded into an inorganic polymer while the imprinting process occurred. The synthesized GOQDs-embedded silica molecularly imprinting polymer (SMIP) showed strong fluorescent emission at 450 nm by exciting at 360 nm. The fluorescence intensity of GOQDs-embedded SMIP was quenched effectively by adsorption of EN as a template molecule. The quenching corresponded to EN concentration in a linear range of at least 0.40–6.00 μM with a limit of detection of 0.31 μM. The designed chemical nanosensor was successfully applied to the analysis of entacapone in some pharmaceutical tablets also containing carbidopa and levodopa (RSD 3.8%).

介绍了一种灵敏的荧光化学纳米传感器，用于检测药物样品中的entacapone（EN）。EN是一种硝基儿茶酚类药物，可作为儿茶酚-O的选择性和可逆抑制剂-甲基转移酶被广泛用于治疗帕金森氏病。分子印迹技术和氧化石墨烯量子点（GOQD）用于设计EN荧光纳米传感器。GOQD被嵌入到无机聚合物中，同时发生了压印过程。合成的嵌入GOQDs的二氧化硅分子印迹聚合物（SMIP）通过在360 nm处激发而在450 nm处显示出强荧光发射。通过嵌入EN作为模板分子，可以有效地猝灭嵌入GOQDs的SMIP的荧光强度。猝灭对应于EN浓度至少在0.40–6.00μM的线性范围内，检出限为0.31μM。设计的化学纳米传感器已成功用于一些也含有卡比多巴和左旋多巴的药物片剂中的entacapone的分析（RSD 3。