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Regrowth-delay body as a bacterial subcellular structure marking multidrug-tolerant persisters
Cell Discovery ( IF 13.0 ) Pub Date : 2019-01-22 , DOI: 10.1038/s41421-019-0080-3
Jiayu Yu , Yang Liu , Huijia Yin , Zengyi Chang

Bacteria have long been recognized to be capable of entering a phenotypically non-growing persister state, in which the cells exhibit an extended regrowth lag and a multidrug tolerance, thus posing a great challenge in treating infectious diseases. Owing to their non-inheritability, low abundance of existence, lack of metabolic activities, and high heterogeneity, properties of persisters remain poorly understood. Here, we report our accidental discovery of a subcellular structure that we term the regrowth-delay body, which is formed only in non-growing bacterial cells and sequesters multiple key proteins. This structure, that dissolves when the cell resumes growth, is able to be viewed as a marker of persisters. Our studies also indicate that persisters exhibit different depth of persistence, as determined by the status of their regrowth-delay bodies. Our findings imply that suppressing the formation and/or promoting the dissolution of regrowth-delay bodies could be viable strategies for eradicating persisters.



中文翻译:

再生滞后体是一种细菌亚细胞结构,标记了耐多药的持久性

长期以来,细菌一直被认为能够进入表型不生长的持久性状态,其中细胞表现出延长的再生滞后和多药耐受性,因此在治疗传染病方面提出了巨大的挑战。由于它们的不可继承性,存在的低丰度,缺乏代谢活性以及高度的异质性,对持久性的性质仍然知之甚少。在这里,我们报告了偶然发现的一个亚细胞结构,我们称其为再生长延迟体,它仅在未生长的细菌细胞中形成,并隔离了多种关键蛋白质。当细胞恢复生长时溶解的这种结构可以被视为持久性的标志。我们的研究还表明,坚持者表现出不同的坚持深度,由它们的再生延迟体的状态决定。我们的发现暗示抑制再生长延迟体的形成和/或促进再生长延迟体的溶解可能是消除持久性的可行策略。

更新日期:2019-11-18
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