The physical-chemical effects of drugs/lipidic interfaces interactions are still little known, justifying investigations using model systems. Here, we investigated a drug with potential biological activity against microbial and tumorigenic cells, thymol, using phosphotadylserine as cellular membrane models. Surface pressure-area isotherms showed that selected amounts of thymol expand the monolayers and decreased its elasticity. Vibrational spectroscopy and Brewster angle microscopy pointed that thymol adsorbs on the lipid polar heads, affecting the aliphatic chain gauche conformations, causing aggregation at the interface. This indicated distinctive molecular accommodations of thymol along the phospholipidic structures, which is associated to its biological effect in natural membranes.

药物/脂质界面相互作用的物理化学效应仍然鲜为人知，这证明了使用模型系统进行研究的合理性。在这里，我们研究了使用磷酸tadadylserine作为细胞膜模型对微生物和致瘤细胞百里酚具有潜在生物活性的药物。表面压力-面积等温线表明，选定量的百里香酚使单分子层膨胀并降低其弹性。振动光谱法和布鲁斯特角显微镜表明，百里香酚吸附在脂质极性头上，影响脂族链状构象，导致界面聚集。这表明百里酚沿磷脂结构具有独特的分子适应性，这与其在天然膜中的生物学作用有关。