当前位置：
X-MOL 学术
›
J. Thorac. Oncol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
The relationship between air pollution and lung cancer in non-smokers in Taiwan
Journal of Thoracic Oncology ( IF 21.0 ) Pub Date : 2019-05-01 , DOI: 10.1016/j.jtho.2018.12.033 Chien-Hua Tseng , Ben-Jei Tsuang , Chun-Ju Chiang , Kai-Chen Ku , Jeng-Sen Tseng , Tsung-Ying Yang , Kuo-Hsuan Hsu , Kun-Chieh Chen , Sung-Liang Yu , Wen-Chung Lee , Tsang-Wu Liu , Chang-Chuan Chan , Gee-Chen Chang
Journal of Thoracic Oncology ( IF 21.0 ) Pub Date : 2019-05-01 , DOI: 10.1016/j.jtho.2018.12.033 Chien-Hua Tseng , Ben-Jei Tsuang , Chun-Ju Chiang , Kai-Chen Ku , Jeng-Sen Tseng , Tsung-Ying Yang , Kuo-Hsuan Hsu , Kun-Chieh Chen , Sung-Liang Yu , Wen-Chung Lee , Tsang-Wu Liu , Chang-Chuan Chan , Gee-Chen Chang
Introduction: For never‐smokers (smoked <100 lifetime cigarettes), lung cancer (LC) has emerged as an important issue. We aimed to investigate the effects of prevalence changes in tobacco smoking and particulate matter (PM) 2.5 (PM2.5) levels on LC in Taiwan, in relation to contrasting PM2.5 levels, between Northern Taiwan (NT) and Southern Taiwan (ST). Methods: We reviewed 371,084 patients with LC to assess smoking prevalence and correlations between the incidence of adenocarcinoma lung cancer (AdLC) and non‐AdLC. Two subsets were selected to assess different AdLC stage trends and the effect of PM2.5 on survival of patients with AdLC. Results: From 1995 to 2015, the proportion of male adult ever‐smokers decreased from 59.4% to 29.9% whereas the female smoking rate remained low (3.2% to 5.3%). AdLC incidence in males and females increased from 9.06 to 23.25 and 7.05 to 24.22 per 100,000 population, respectively. Since 1993, atmospheric visibility in NT improved (from 7.6 to 11.5 km), but deteriorated in ST (from 16.3 to 4.2 km). The annual percent change in AdLC stages IB to IV was 0.3% since 2009 (95% confidence interval [CI]: ‐1.9%–2.6%) in NT, and 4.6% since 2007 (95% CI: 3.3%–5.8%) in ST; 53% patients with LC had never smoked. Five‐year survival rates for never‐smokers, those with EGFR wild‐type genes, and female patients with AdLC were 12.6% in NT and 4.5% in ST (hazard ratio: 0.79, 95% CI: 0.70–0.90). Conclusions: In Taiwan, greater than 50% of patients with LC had never smoked. PM2.5 level changes can affect AdLC incidence and patient survival.
更新日期：2019-05-01
京公网安备 11010802027423号