This study employed a molecularly imprinted composite (MIC) to develop a selective and very sensitive sensor for the determination of quinine. To fabricate the MIC sensor, 3-methyl-4-nitrophenol (MNP) and L-tyrosine (Tyr) were simultaneously electrodeposited in acidic media containing HAuCl₄ to entrap Au nanoparticles (AuNPs) into the formed composite network. The effect of Tyr on the sensitivity and selectivity of the sensor and its electrochemical performance were evaluated. The signal reduction of the Fe²⁺probe during differential pulse voltammetry (DPV) was used to determine the concentration of quinine. The signal was found to be linear over the quinine concentration range of 0.1 to 1000 pM with a detection limit of 0.05 pM. The sensor was used to determine the quinine content of several plasma and urine samples.

这项研究采用了分子印迹复合材料（MIC）来开发选择性高灵敏度的奎宁传感器。为了制造MIC传感器，将3-甲基-4-硝基苯酚（MNP）和L-酪氨酸（Tyr）同时电沉积在含有HAuCl _4的酸性介质中，以将Au纳米颗粒（AuNPs）捕获到形成的复合网络中。评估了Tyr对传感器的灵敏度和选择性及其电化学性能的影响。Fe ²⁺的信号降低差分脉冲伏安法（DPV）期间使用探针测定奎宁的浓度。发现该信号在0.1至1000 pM的奎宁浓度范围内呈线性，检出限为0.05 pM。该传感器用于确定几种血浆和尿液样品中的奎宁含量。