To the Editor, As Zhou and Reveille note,1 MICA is a functionally enticing candidate gene for ankylosingspondylitis (AS). It is however challenging to study because of the technical difficulty of direct genotyping studies of the locus, its proximity and strong linkage disequilibrium with HLA-B , and the fact that it is subject to major population stratification effects. We recently performed an association study of common MICA alleles with AS susceptibility and observed no evidence of association in either HLA-B*27 positive or negative stratified analyses.2 In this study, …

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回应：“对文章“基于插补的 MICA 等位基因对强直性脊柱炎易感性的分析”的回应，周等人

致编辑，正如 Zhou 和 Reveille 指出的那样，1 MICA 是强直性脊柱炎 (AS) 的功能诱人候选基因。然而，由于基因座直接基因分型研究的技术难度、其与 HLA-B 的邻近性和强连锁不平衡以及它受主要人群分层效应的影响，研究具有挑战性。我们最近对常见 MICA 等位基因与 AS 易感性进行了关联研究，在 HLA-B*27 阳性或阴性分层分析中均未观察到关联证据。 2 在这项研究中，……