Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.,Immunity

当前位置： X-MOL 学术 › Immunity › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.
Immunity ( IF 25.5 ) Pub Date : 2019-01-22 , DOI: 10.1016/j.immuni.2018.12.012
Xiaoyu Liu ₁ , Daniel P Nemeth ₂ , Daniel B McKim ₃ , Ling Zhu ₄ , Damon J DiSabato ₅ , Olimpia Berdysz ₁ , Gowthami Gorantla ₁ , Braedan Oliver ₁ , Kristina G Witcher ₆ , Yufen Wang ₂ , Christina E Negray ₁ , Rekha S Vegesna ₁ , John F Sheridan ₅ , Jonathan P Godbout ₇ , Matthew J Robson ₈ , Randy D Blakely ₉ , Phillip G Popovich ₁₀ , Staci D Bilbo ₁₁ , Ning Quan ₂

Affiliation

Institute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Institute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, OH 43210, USA; Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA.
Institute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, OH 43210, USA; Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA; Department of Animal Science, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.
West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Institute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, OH 43210, USA; Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA; Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA.
Institute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, OH 43210, USA; Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA.
Institute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, OH 43210, USA; Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA; Center for Brain and Spinal Cord Repair, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA.
Department of Biomedical Science, Charles E. Schmidt College of Medicine and Brain Institute, Florida Atlantic University, Jupiter, FL 33458, USA.
Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA; Center for Brain and Spinal Cord Repair, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Pediatrics and Neuroscience, Harvard Medical School, Lurie Center for Autism, Massachusetts General Hospital for Children, Boston, MA 02126, USA.

Interleukin-1 (IL-1) signaling is important for multiple potentially pathogenic processes in the central nervous system (CNS), but the cell-type-specific roles of IL-1 signaling are unclear. We used a genetic knockin reporter system in mice to track and reciprocally delete or express IL-1 receptor 1 (IL-1R1) in specific cell types, including endothelial cells, ventricular cells, peripheral myeloid cells, microglia, astrocytes, and neurons. We found that endothelial IL-1R1 was necessary and sufficient for mediating sickness behavior and drove leukocyte recruitment to the CNS and impaired neurogenesis, whereas ventricular IL-1R1 was critical for monocyte recruitment to the CNS. Although microglia did not express IL-1R1, IL-1 stimulation of endothelial cells led to the induction of IL-1 in microglia. Together, these findings describe the structure and functions of the brain's IL-1R1-expressing system and lay a foundation for the dissection and identification of IL-1R1 signaling pathways in the pathogenesis of CNS diseases.

中文翻译：

细胞类型特定的白介素1受体1在大脑中的信号调节不同的神经免疫活性。

白介素-1（IL-1）信号传导对于中枢神经系统（CNS）中的多个潜在致病过程很重要，但是IL-1信号传导的细胞类型特异性作用尚不清楚。我们在小鼠中使用了基因敲入报告系统，以追踪和相应地删除或表达特定细胞类型中的IL-1受体1（IL-1R1），包括内皮细胞，心室细胞，外周髓样细胞，小胶质细胞，星形胶质细胞和神经元。我们发现内皮IL-1R1是介导疾病行为和驱使白细胞募集到中枢神经系统并损害神经发生的必要和充分条件，而心室IL-1R1对于单核细胞募集到中枢神经系统至关重要。尽管小胶质细胞不表达IL-1R1，但是内皮细胞的IL-1刺激导致小胶质细胞中IL-1的诱导。一起，

更新日期：2019-01-22

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11