Plant diseases, caused by various microorganisms, including viruses, bacteria, fungi, protozoa and nematodes, affect agricultural practices and result in significant crop losses. Fungal pathogens are the major cause of plant diseases and infect most plants. Agrochemicals play a significant role in plant disease management to ensure a sustainable and productive agricultural system. However, the intensive use of chemicals has adverse effects on humans and ecosystem functioning and also reduces agricultural sustainability. A sustainable agriculture is achieved through reduction or elimination of fertilizers and agrochemicals, resulting in minimal impact to the environment. Recently, the use of antagonistic endophytes as biocontrol agents is drawing special attention as an attractive option for management of some plant diseases, resulting in minimal impact to the environment. Endophytes that resides asymptomatically within a plant, have the potential to provide a source of candidate strains for potential biocontrol applications. This review addresses biocontrol methods using endophytic fungi such as Colletotrichum, Cladosporium, Fusarium, Pestalotiopsis and Trichoderma species as an attractive option for management of some plant diseases. Potential endophytes are screened in vitro and in vivo to test their antagonistic actions by different mechanisms, including mycoparasitism, production of lytic enzymes and/or antibiotics and induction of plant defenses. Currently, efforts are being made to commercialize these biocontrol agents. A continued research pipeline consisting of screening, in vitro and in vivo testing, biomass production and commercialization of endophytes as biocontrol agents may contribute to sustainable agriculture.

由各种微生物（包括病毒，细菌，真菌，原生动物和线虫）引起的植物病害影响农业生产，并造成严重的农作物损失。真菌病原体是植物病害的主要原因，并感染大多数植物。农用化学品在植物病害管理中起着重要作用，以确保可持续和高产的农业系统。但是，大量使用化学品会对人类和生态系统的功能产生不利影响，还会降低农业的可持续性。通过减少或消除肥料和农用化学品来实现可持续农业，从而对环境的影响最小。最近，拮抗性内生菌作为生物防治剂的使用正引起人们的特别注意，因为它是控制某些植物病害的有吸引力的选择，对环境的影响最小。无症状地生活在植物中的内生菌有可能为潜在的生物防治应用提供候选菌株的来源。这篇评论针对使用内生真菌的生物防治方法，例如炭疽菌，枝孢菌属，镰刀菌，Pestalotiopsis和木霉属种作为管理某些植物病害的有吸引力的选择。在体外和体内筛选潜在的内生菌，以通过不同的机制测试其拮抗作用，包括支原体寄生，分解酶和/或抗生素的产生以及植物防御的诱导。当前，正在努力使这些生物防治剂商业化。持续的研究流程，包括体外和体内筛选 测试，生物质生产以及作为生物防治剂的内生菌的商业化可能有助于可持续农业。