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Reply: Interaction or mediation by adult obesity of the relation between fetal famine exposure and type 2 diabetes?
International Journal of Epidemiology ( IF 6.4 ) Pub Date : 2019-01-21 , DOI: 10.1093/ije/dyy295 Ruogu Meng 1 , Jun Lv 1, 2 , Liming Li 1
International Journal of Epidemiology ( IF 6.4 ) Pub Date : 2019-01-21 , DOI: 10.1093/ije/dyy295 Ruogu Meng 1 , Jun Lv 1, 2 , Liming Li 1
Affiliation
We thank Li and Lumey for their interest in our study. As mentioned by Li and Lumey, the associations of fetal exposure to famine with adult obesity and diabetes risks have been observed in Dutch famine studies. Also, there is a well-established association between obesity and diabetes. After the combination of non-exposed and early-childhood-exposed participants as the reference, our study reported the similar findings that both fetal exposure to the Chinese Great Famine and adult overweight or obesity were associated with increased risks of type 2 diabetes.1 However, the relations between famine exposure, adult obese status and diabetes risk do not necessarily lead to an interaction between the effects of famine exposure and adult obesity on diabetes risk. Similarly, two previous studies also did not find that general obesity during adulthood interacts with the Chinese famine experience in early life to increase the risk of type 2 diabetes.2,3 To the best of our knowledge, our study is the first to investigate the effect of the interaction of fetal famine exposure with abdominal obesity on diabetes risk.
更新日期：2019-01-21
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