BACKGROUND Cross-sectional studies indicate an age-related decline in vitamin B6 status. Because longitudinal studies are lacking, the present study investigates the long-term association between age and vitamin B6 status in older adults by considering potential confounding factors. METHODS The study population consists of 249 women and 111 men aged ≥ 60 years, who had at least three follow-ups between 1996 and 2014 with complete data records on relevant parameters. Vitamin B6 status was assessed by serum pyridoxal 5'-phosphate (PLP) concentrations measured by high-performance liquid chromatography. Linear mixed models were used to analyze the influence of age, sex, body composition, supplements, diet, lifestyle, and serum creatinine on PLP concentrations. RESULTS At baseline, 37% of the subjects showed PLP concentrations < 30 nmol/L and more than half failed to meet the recommended dietary intake. Longitudinal analyses revealed that age, use of supplements and protein intake were positive determinants of PLP concentrations, whereas body fat showed a negative impact. No influence of sex, dietary vitamin B6 intake, lifestyle factors or serum creatinine on PLP concentrations was found. CONCLUSION The present study provides no evidence that in the course of aging PLP concentrations decline between 60 and 90 years. However, age-related changes in body composition, such as an increased ratio of fat mass to fat-free mass may negatively affect vitamin B6 status.

中文翻译：

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社区老年人中维生素B6状况的决定因素：一项为期18年的纵向研究。

背景技术横断面研究表明与年龄有关的维生素B6状态下降。由于缺乏纵向研究，因此本研究通过考虑潜在的混杂因素来研究老年人的年龄与维生素B6状态之间的长期关联。方法研究人群由249名女性和111名年龄≥60岁的男性组成，他们在1996年至2014年期间至少进行了3次随访，并记录了相关参数的完整数据。维生素B6的状态通过高效液相色谱法测定的血清吡ido醛5'-磷酸（PLP）浓度进行评估。线性混合模型用于分析年龄，性别，身体组成，补品，饮食，生活方式和血清肌酐对PLP浓度的影响。结果在基线时，37％的受试者的PLP浓度< 30 nmol / L和一半以上未能达到建议的饮食摄入量。纵向分析显示，年龄，补充剂的使用和蛋白质摄入量是PLP浓度的积极决定因素，而体脂则显示负面影响。未发现性别，饮食中维生素B6的摄入量，生活方式因素或血清肌酐对PLP浓度的影响。结论本研究没有提供证据表明在衰老过程中PLP浓度会在60至90年之间下降。但是，与年龄相关的身体组成变化，例如脂肪量与无脂肪量的比率增加，可能会对维生素B6的状况产生负面影响。而身体脂肪显示出负面影响。未发现性别，饮食中维生素B6的摄入量，生活方式因素或血清肌酐对PLP浓度的影响。结论本研究没有提供证据表明在衰老过程中PLP浓度会在60至90年之间下降。但是，与年龄相关的身体组成变化，例如脂肪量与无脂肪量的比率增加，可能会对维生素B6的状况产生负面影响。而身体脂肪显示出负面影响。未发现性别，饮食中维生素B6的摄入量，生活方式因素或血清肌酐对PLP浓度的影响。结论本研究没有提供证据表明在衰老过程中PLP浓度会在60至90年之间下降。但是，与年龄相关的身体组成变化，例如脂肪量与无脂肪量的比率增加，可能会对维生素B6的状况产生负面影响。