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An amygdalar neural ensemble that encodes the unpleasantness of pain
Science ( IF 44.7 ) Pub Date : 2019-01-17 , DOI: 10.1126/science.aap8586
Gregory Corder 1, 2, 3, 4 , Biafra Ahanonu 5, 6, 7 , Benjamin F Grewe 5, 7 , Dong Wang 1 , Mark J Schnitzer 5, 6, 7, 8 , Grégory Scherrer 1, 2, 3, 4, 9
Affiliation  

The emotional dimension of pain The unpleasantness of pain is an emotional phenomenon distinct from pain's sensory qualities. To study how the brain processes pain-related emotions, Corder et al. used in vivo neural calcium imaging in freely behaving mice. They identified brain circuits that respond to pain and directly tested their causal role in motivational behaviors associated with acute and chronic pain. Science, this issue p. 276 A population of nerve cells in the basolateral amygdala represents the aversive qualities of pain in mice. Pain is an unpleasant experience. How the brain’s affective neural circuits attribute this aversive quality to nociceptive information remains unknown. By means of time-lapse in vivo calcium imaging and neural activity manipulation in freely behaving mice encountering noxious stimuli, we identified a distinct neural ensemble in the basolateral amygdala that encodes the negative affective valence of pain. Silencing this nociceptive ensemble alleviated pain affective-motivational behaviors without altering the detection of noxious stimuli, withdrawal reflexes, anxiety, or reward. Following peripheral nerve injury, innocuous stimuli activated this nociceptive ensemble to drive dysfunctional perceptual changes associated with neuropathic pain, including pain aversion to light touch (allodynia). These results identify the amygdalar representations of noxious stimuli that are functionally required for the negative affective qualities of acute and chronic pain perception.

中文翻译:

杏仁核神经系统编码疼痛的不愉快

疼痛的情绪维度 疼痛的不愉快是一种不同于疼痛感官品质的情绪现象。为了研究大脑如何处理与疼痛相关的情绪,Corder 等人。用于自由行为小鼠的体内神经钙成像。他们确定了对疼痛有反应的大脑回路,并直接测试了它们在与急性和慢性疼痛相关的动机行为中的因果作用。科学,这个问题 p。276 基底外侧杏仁核中的神经细胞群代表了小鼠对疼痛的厌恶性质。疼痛是一种不愉快的经历。大脑的情感神经回路如何将这种厌恶品质归因于伤害性信息仍然未知。通过延时体内钙成像和神经活动操纵,自由行为的小鼠遇到有害刺激,我们在基底外侧杏仁核中发现了一个独特的神经集合,它编码了疼痛的负面情感效价。沉默这种伤害性整体可以减轻疼痛的情感动机行为,而不会改变对有害刺激、退缩反射、焦虑或奖励的检测。周围神经损伤后,无害的刺激会激活这种伤害性整体,以驱动与神经性疼痛相关的功能失调的知觉变化,包括对轻触的疼痛厌恶(异常性疼痛)。这些结果确定了急性和慢性疼痛感知的负面情感品质在功能上所需的有害刺激的杏仁核表征。沉默这种伤害性整体可以减轻疼痛的情感动机行为,而不会改变对有害刺激、退缩反射、焦虑或奖励的检测。周围神经损伤后,无害的刺激会激活这种伤害性整体,以驱动与神经性疼痛相关的功能失调的知觉变化,包括对轻触的疼痛厌恶(异常性疼痛)。这些结果确定了急性和慢性疼痛感知的负面情感品质在功能上所需的有害刺激的杏仁核表征。沉默这种伤害性整体可以减轻疼痛的情感动机行为,而不会改变对有害刺激、退缩反射、焦虑或奖励的检测。周围神经损伤后,无害的刺激会激活这种伤害性整体,以驱动与神经性疼痛相关的功能失调的知觉变化,包括对轻触的疼痛厌恶(异常性疼痛)。这些结果确定了急性和慢性疼痛感知的负面情感品质在功能上所需的有害刺激的杏仁核表征。包括对轻触的疼痛厌恶(异常性疼痛)。这些结果确定了急性和慢性疼痛感知的负面情感品质在功能上所需的有害刺激的杏仁核表征。包括对轻触的疼痛厌恶(异常性疼痛)。这些结果确定了急性和慢性疼痛感知的负面情感品质在功能上所需的有害刺激的杏仁核表征。
更新日期:2019-01-17
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