Background

Breast arterial calcification (BAC) may be a predictor of cardiovascular events and is highly prevalent in persons with end-stage kidney disease. However, few studies to date have examined the association between mild-to-moderate kidney function and proteinuria with BAC.

Methods

We prospectively enrolled women with no prior cardiovascular disease aged 60 to 79 years undergoing mammography screening at Kaiser Permanente Northern California between 10/24/2012 and 2/13/2015. Urine albumin-to-creatinine ratio (uACR), along with specific laboratory, demographic, and medical data, were measured at the baseline visit. Baseline estimated glomerular filtration rate (eGFR), medication history, and other comorbidities were identified from self-report and/or electronic medical records. BAC presence and gradation (mass) was measured by digital quantification of full-field mammograms.

Results

Among 3,507 participants, 24.5% were aged ≥70 years, 63.5% were white, 7.5% had eGFR <60 ml/min/1.73m², with 85.7% having uACR ≥30 mg/g and 3.3% having uACR ≥300 mg/g. The prevalence of any measured BAC (>0 mg) was 27.9%. Neither uACR ≥30 mg/g nor uACR ≥300 were significantly associated with BAC in crude or multivariable analyses. Reduced eGFR was associated with BAC in univariate analyses (odds ratio 1.53, 95% CI: 1.18–2.00), but the association was no longer significant after adjustment for potential confounders. Results were similar in various sensitivity analyses that used different BAC thresholds or analytic approaches.

Conclusions

Among women without cardiovascular disease undergoing mammography screening, reduced eGFR and albuminuria were not significantly associated with BAC.

中文翻译：

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没有临床心血管疾病的女性的肾脏功能，蛋白尿和乳房动脉钙化：MINERVA研究

背景

乳腺动脉钙化（BAC）可能是心血管事件的预测指标，在终末期肾脏疾病患者中非常普遍。然而，迄今为止，很少有研究检查轻度至中度肾功能与BAC蛋白尿之间的关系。

方法

我们在2012年10月24日至2015年2月13日之间，招募了年龄在60到79岁之间且无先前心血管疾病的女性，他们在北加利福尼亚州的Kaiser Permanente进行了乳房X线检查。在基线访视时测量尿白蛋白/肌酐比值（uACR），以及特定的实验室，人口统计学和医学数据。从自我报告和/或电子病历中确定基线估计的肾小球滤过率（eGFR），用药史和其他合并症。BAC的存在和等级（质量）是通过对全场乳房X线照片进行数字量化来测量的。

结果

在3,507名参与者中，年龄≥70岁的占24.5％，白人占63.5％，eGFR <60 ml / min / 1.73m ²占7.5％，uACR≥30mg / g占85.7％，uACR≥300mg / g占3.3％。 G。任何测得的BAC（> 0 mg）的患病率为27.9％。在粗略或多变量分析中，uACR≥30mg / g和uACR≥300均与BAC无显着相关性。eGFR降低与单因素分析中的BAC相关（比值比为1.53，95％CI：1.18-2.00），但在对潜在的混杂因素进行调整后，该相关性不再显着。在使用不同BAC阈值或分析方法的各种敏感性分析中，结果相似。

结论

在没有心血管疾病的女性接受乳房X线检查的情况下，eGFR降低和蛋白尿与BAC无关。