We propose a strategy to counteract the salt-driven disassembly of multiliposomal complexes made by electrostatic co-assembly of anionic small unilamellar liposomes and cationic star-shaped polyelectrolytes (made of quaternized poly(dimethylaminoethyl methacrylate) (qPDMAEMA₁₀₀)_3.1). The combined action of (qPDMAEMA₁₀₀)_3.1 and a nonionic star-shaped polymer (PEO₁₂-b-PPO₄₅)₄, which comprises diblock copolymer arms uniting a poly(ethylene oxide) PEO inner block and a poly(propylene oxide) PPO terminal block, leads to a stabilization of these complexes against disintegration in saline solutions. Hereby, the anchoring of the PPO terminal blocks to the lipid bilayer and the bridging between several liposomes are at the origin of the promoted structural stability. Two-focus fluorescence correlation spectroscopy verifies the formation of multiliposomal complexes with (PEO₁₂-b-PPO₄₅)₄. The polyelectrolyte and the amphiphilic polymer work synergistically, as the joint action still assures some membrane integrity, which is not seen for the mere (PEO₁₂-b-PPO₄₅)₄—liposome interaction alone.

我们提出了一种策略来抵消由阴离子小单层脂质体和阳离子星形聚电解质（由季铵化聚（甲基丙烯酸二甲氨基乙酯）（ q PDMAEMA ₁₀₀）_3.1制成）静电共组装而成的多脂质体复合物的盐驱动分解。( q PDMAEMA ₁₀₀ ) _3.1和非离子星形聚合物 (PEO ₁₂ - b -PPO ₄₅ ) ₄的联合作用，该聚合物包含将聚环氧乙烷 PEO 内部嵌段和聚环氧丙烷结合在一起的二嵌段共聚物臂PPO 接线盒可稳定这些复合物，防止其在盐水溶液中分解。因此，PPO 末端嵌段与脂质双层的锚定以及几个脂质体之间的桥接是促进结构稳定性的根源。双焦点荧光相关光谱验证了与(PEO ₁₂ - b -PPO ₄₅ ) ₄的多脂质体复合物的形成。_{聚电解质和两亲性聚合物协同作用，因为联合作用仍然确保了一定的膜完整性，而这对于单独的(PEO 12} - b -PPO ₄₅ ) ₄ -脂质体相互作用是看不到的。