Aim

The aim of our study was to evaluate the potential role of resistin in estimating the 30 days prognosis in patients with hypoxic-ischemic organ injury who survived after a cardiac arrest (CA).

Materials and methods

The study included 40 patients resuscitated after a non-traumatic out-of-hospital CA admitted in Emergency Department (ED). All patients were followed for 30 days after CA or until death. Clinical data on admission were recorded. Blood samples were collected on admission in ED (0-time interval), and at 6, 12, 24, 48- and 72-hours following resuscitation. Serum concentrations of resistin, S100B and neuron specific enolase (NSE) were measured. Several predictive scores for the mortality at 30 days were created with logistic regressions.

Results

At each time interval, median serum levels of resistin and S100 B were significantly higher in non-survivors compared to survivors. For NSE, plasma levels were significantly lower in survivors as compared to non-survivors at 48 and 72 hours, respectively. Accurate predictive scores for 30-days mortality were the ones which included the values of resistin and S100B measured at 12 hours after admittance [AUC 0.938 (0.813–0.989), sensitivity 85.71% (67.3%– 96%), specificity 91.67% (61.5%’99.8%), p<0.001], which included the values of all three markers measured at 12 hours after admittance [AUC 0.955 (0.839–0.995), sensitivity 82.14% (63.1%’93.9%), specificity 100.00% (73.5%’100.0%), p<0.001] and the that included the values of resistin and S-100B at 6 hours together with serum lactate on admission [AUC = 0.994 (0.901–1.0), sensitivity 96.4% (81.7%’99.9%), specificity 100.00% (73.5%’100.0%), p<0.001].

Conclusion

In our study, serum levels of resistin or a combination of resistin with S-100B or resistin with S-100B and lactate, were highly predictive for 30 days mortality in resuscitated patients after CA. Further studies on large number of patients are needed to confirm our data.

中文翻译：

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抵抗素-它可以作为心脏骤停后存活的患者预后的新的早期标记吗？初步研究

目的

我们研究的目的是评估抵抗素在评估心脏骤停（CA）后存活的缺氧缺血性器官损伤患者30天预后中的潜在作用。

材料和方法

该研究包括40名在急诊科（ED）住院的非创伤性院外CA后复苏的患者。在CA后30天或直至死亡之前，对所有患者进行随访。记录入院时的临床数据。入院时在ED（0次间隔）以及复苏后第6、12、24、48和72小时收集血样。测量血清抵抗素，S100B和神经元特异性烯醇化酶（NSE）的浓度。使用logistic回归创建了30天死亡率的几个预测得分。

结果

在每个时间间隔，非幸存者的抵抗素和S100 B血清中值均显着高于幸存者。对于NSE，分别在48小时和72小时时，幸存者的血浆水平显着低于非幸存者。准确的30天死亡率预测得分包括入院后12小时测得的抵抗素和S100B值[AUC 0.938（0.813–0.989），敏感性85.71％（67.3％–96％），特异性91.67％（61.5） ％'99 .8％），p <0.001]，其中包括在进入[AUC 0.955（0.839-0.995）后12小时测得的所有三种标记物的值，敏感性82.14％（63.1％'93 .9％），特异性100.00％（73.5） ％'100.0％），p <0.001]，其中包括入院时6小时的抵抗素和S-100B值以及入院时的血清乳酸[AUC = 0.994（0.901-1.0），敏感性96.4％（81。

结论

在我们的研究中，对于CA术后复苏患者30天的死亡率，血清抵抗素或抵抗素与S-100B或抵抗素与S-100B和乳酸的组合具有很高的预测价值。需要对大量患者进行进一步研究以证实我们的数据。