The aim of this study was to obtain and investigate new materials for cosmetic or dermatological applications. Microcapsules typically have a particle size from 1 to 1000 μm in diameter and they consist of an inner core containing an active agent, covered by a layer of polymer. Encapsulation technology have been used for improving the long-term stability of active substances and enhancing and prolonging the effectiveness of active ingredients. Microcapsules were obtained by coacervation/cross-linking method. The core was made of retinyl palmitate and was coated with poly(vinyl alcohol). In the next step, different quantities of microcapsules were incorporated into polymer matrices, which were prepared from collagen isolated from fish scales of Esox lucius in our laboratory. Polymer matrices were cross-linked with EDC/NHS (1-ethyl-3(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide) mixture. The Scanning Electron Microscopy confirmed the porous structure of the obtained materials with the presence of microcapsules. The highest values of Young's modulus were observed for the collagen matrices with incorporated larger amount of PVA microcapsules. All the matrices had high swelling properties. Based on the analysis, it was found that collagen matrices with incorporated retinyl palmitate-loaded PVA microcapsules are a promising material for the cosmetic or pharmaceutical industry.

这项研究的目的是获得和研究用于化妆品或皮肤病学应用的新材料。微胶囊的粒径通常为直径1至1000μm，它们由含有活性剂的内芯组成，内芯被聚合物层覆盖。包囊技术已用于改善活性物质的长期稳定性并增强和延长活性成分的效力。通过凝聚/交联法获得微胶囊。芯由棕榈酸视黄酯制成，并涂有聚乙烯醇。在下一步中，将不同数量的微胶囊掺入聚合物基质中，这些基质是从从Esox lucius鱼鳞中分离出的胶原蛋白制备的在我们的实验室。用EDC / NHS（1-乙基-3（3-二甲基氨基丙基）碳二亚胺/ N-羟基琥珀酰亚胺）混合物使聚合物基质交联。扫描电子显微镜证实所获得的材料具有微囊的多孔结构。对于掺入大量PVA微胶囊的胶原蛋白基质，观察到杨氏模量的最高值。所有基质都具有高溶胀性能。根据分析，发现掺入棕榈酸视黄酯的PVA微胶囊的胶原蛋白基质是化妆品或制药行业的有前途的材料。