A mild and efficient trifluoromethylation of imidazopyridines with Togni’s reagent in the presence of inexpensive base has been realized at room temperature. This methodology has several advantages: (1) using efficient copper(I) as catalyst and inexpensive K₃PO₄ as base, (2) no additional oxidants required for this reaction. (3) good functional group tolerance. An array of trifluoromethylated imidazopyridines with broad functionalities were obtained in acceptable yields.

中文翻译：

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用Togni试剂铜（I）催化的咪唑杂环杂环直接CH三氟甲基化

在室温下，在便宜的碱存在下，用Togni试剂温和有效地进行了咪唑并吡啶的三氟甲基化反应。该方法具有几个优点：（1）使用高效的铜（I）作为催化剂，使用廉价的K ₃ PO ₄作为碱，（2）该反应不需要其他氧化剂。（3）良好的功能群耐受性。以可接受的产率获得了具有宽泛功能的三氟甲基化咪唑并吡啶的阵列。