A series of novel 1, 2, 4-triazolo isoquinoline derivatives (8a-8p) were synthesized starting from 2-phenylethan-1-ol derivative (1) in a 7 step synthetic sequence. The key step in the scheme involves 1, 3-dipolar [3 + 2] cycloaddition of azomethine imine and ethyl cyanoformate as unknown reaction protocol. We have demonstrated the hydrolysis of both ester and benzoyl group in a single step and the corresponding carboxylic acid derivatives were coupled with various amines to generate unknown 1, 2, 4-triazolo isoquinoline derivatives The structures of the compounds (8a-8p) were characterized by ¹H NMR, ¹³C NMR and HRMS analysis.

从2-苯基乙-1-醇衍生物（1）开始，按照7步合成顺序合成了一系列新颖的1、2、4-三唑并异喹啉衍生物（8a-8p）。该方案的关键步骤涉及偶氮甲亚胺和氰基甲酸乙酯的1，3-偶极[3 + 2]环加成反应，作为未知的反应方案。我们已经证明了酯和苯甲酰基都可以在一个步骤中水解，并且相应的羧酸衍生物与各种胺偶联生成未知的1、2、4-三唑并异喹啉衍生物。化合物（8a-8p）的结构得到了表征通过¹ H NMR，¹³ C NMR和HRMS分析。