The nanoencapsulation of curcuminoids extracted from Curcuma longa L. and an evaluation of their cytotoxic, enzymatic, antioxidant and anti-inflammatory activities†,Food & Function

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The nanoencapsulation of curcuminoids extracted from Curcuma longa L. and an evaluation of their cytotoxic, enzymatic, antioxidant and anti-inflammatory activities†
Food & Function ( IF 5.1 ) Pub Date : 2019-01-15 00:00:00 , DOI: 10.1039/c8fo02431f
Priscila Dayane Freitas dos Santos _{1,

2,

3,

4} , Cristhian Rafael Lopes Francisco _{2,

3,

4,

5} , Aline Coqueiro _{1,

2,

3,

4} , Fernanda Vitória Leimann _{1,

2,

3,

4,

6} , José Pinela _{7,

8,

9,

10} , Ricardo C. Calhelha _{7,

8,

9,

10} , Rafael Porto Ineu _{1,

2,

3,

4} , Isabel C. F. R. Ferreira _{7,

8,

9,

10} , Evandro Bona _{1,

2,

3,

4} , Odinei Hess Gonçalves _{1,

2,

3,

4,

6}

Affiliation

Curcumin, bisdemethoxycurcumin and demethoxycurcumin are the main curcuminoids present in Curcuma longa L. and are known for their bioactivity. However, their low water solubility results in poor bioavailability and therapeutic efficacy. This work aimed to investigate the in vitro modulation capacity on the enzymes acetylcholinesterase (AChE) and glutathione S-transferase (GST), as well as the in vitro antioxidant (OxHLIA and TBARS) and anti-inflammatory activities (RAW 264.7 test) of nanoencapsulated curcuminoids. Cytotoxicity on tumor and non-tumor cell lines was also investigated. Curcuminoid nanoparticles significantly inhibited the in vitro activity of AChE (12% inhibition at 50 μM) and GST (30% inhibition at 5 μM). They presented antioxidant activity and toxic effects against breast adenocarcinoma, lung, cervical and hepatocellular carcinoma cells when dispersed in water. Encapsulated curcuminoids exhibited bioactive properties in aqueous medium (no hydrophobic solvent added), exerting antioxidant and cytotoxic effects and acting on the cholinergic and endogenous antioxidant systems.

中文翻译：

从姜黄提取物中的姜黄素类化合物的纳米封装及其细胞毒性，酶促，抗氧化剂和抗炎活性的评估†

姜黄素，双去甲氧基姜黄素和脱甲氧基姜黄素是姜黄中主要的姜黄素类化合物，并以其生物活性而著称。然而，它们的低水溶性导致不良的生物利用度和治疗功效。这项工作旨在研究乙酰胆碱酯酶（AChE）和谷胱甘肽S-转移酶（GST）的体外调节能力，以及纳米囊化的体外抗氧化剂（OxHLIA和TBARS）和抗炎活性（RAW 264.7测试）姜黄素。还研究了对肿瘤和非肿瘤细胞系的细胞毒性。姜黄素纳米颗粒显着抑制体外AChE（50μM时抑制12％）和GST（5μM时抑制30％）的活性。当分散在水中时，他们表现出对乳腺癌，肺癌，宫颈癌和肝细胞癌细胞的抗氧化活性和毒性作用。封装的姜黄素类化合物在水性介质（不添加疏水溶剂）中表现出生物活性，发挥抗氧化和细胞毒性作用，并作用于胆碱能和内源性抗氧化剂系统。

更新日期：2019-01-15

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