Abstract In practice, the poor formability and high degradation rate of Mg-based alloys are perceived as two major limitations for their more extensive applications in the biomedical field. Selective laser melting (SLM), as one of the advanced additive manufacturing techniques, is potential for the manufacturing of customized Mg-based implants with improved formability and corrosion resistance. Moreover, the integration of bioactive glass (BG) into Mg-based alloys could endow the materials with further enhanced corrosion resistance and favorable biological performance. In the current work, biomedical Mg-based biodegradable composites (ZK30/xBG, x = 0, 5, 10, 15 wt%) with ZK30 alloy as the matrix and BG (45S5) as the reinforcement were fabricated by SLM. The results showed that the BG particles homogeneously distributed in the matrices of SLM-fabricated ZK30/xBG composites. Meanwhile, the introduction of the BG particles led to improved microhardness of the composites. When immersed in simulated body fluid (SBF), more precipitations (primary Ca–P compounds and partial Mg(OH)2) formed on ZK30/10BG and ZK30/15BG surfaces compared to ZK30 and ZK30/5BG group. The hydrogen evolution and electrochemical polarization tests showed that corrosion resistance of various specimens was in the following order: ZK30/10BG > ZK30/5BG > ZK30/15BG > ZK30. In addition, the in vitro cell viability results showed that ZK30/10BG and ZK30/15BG were more cytocompatible than ZK30 and ZK30/5BG. Overall, these results indicate that the combination of SLM technique and BG integration could be used to manufacture ZK30/xBG composites with enhanced corrosion resistance and favorable formability. Moreover, the ZK30/10BG composite is promising for orthopedic applications considering its combination of favorable bioactivity, corrosion resistance and cytocompatibility.

中文翻译：

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用于生物医学应用的选择性激光熔化制备的 ZK30/生物活性玻璃复合材料的体外降解行为和细胞相容性

摘要 在实践中，镁基合金较差的成形性和高降解率被认为是其在生物医学领域更广泛应用的两大限制。选择性激光熔化 (SLM) 作为先进的增材制造技术之一，有可能用于制造具有改进的可成形性和耐腐蚀性的定制镁基植入物。此外，将生物活性玻璃（BG）集成到镁基合金中可以赋予材料进一步增强的耐腐蚀性和良好的生物性能。在目前的工作中，以 ZK30 合金为基体，BG (45S5) 为增强体的生物医用镁基生物可降解复合材料（ZK30/xBG，x = 0, 5, 10, 15 wt%）是通过 SLM 制造的。结果表明，BG 颗粒均匀分布在 SLM 制造的 ZK30/xBG 复合材料的基质中。同时，BG 颗粒的引入提高了复合材料的显微硬度。当浸入模拟体液 (SBF) 时，与 ZK30 和 ZK30/5BG 组相比，在 ZK30/10BG 和 ZK30/15BG 表面上形成了更多的沉淀物（主要的 Ca-P 化合物和部分 Mg(OH)2）。析氢和电化学极化测试表明，各种试样的耐腐蚀性能顺序为：ZK30/10BG > ZK30/5BG > ZK30/15BG > ZK30。此外，体外细胞活力结果表明，ZK30/10BG 和 ZK30/15BG 比 ZK30 和 ZK30/5BG 具有更高的细胞相容性。全面的，这些结果表明，SLM 技术和 BG 集成的结合可用于制造具有增强的耐腐蚀性和良好的成型性的 ZK30/xBG 复合材料。此外，ZK30/10BG 复合材料结合了良好的生物活性、耐腐蚀性和细胞相容性，有望用于骨科应用。