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Defying Death: The (W)hole Truth about the Fate of GSDMD Pores.
Immunity ( IF 25.5 ) Pub Date : 2019-01-15 , DOI: 10.1016/j.immuni.2018.12.032
Charles L Evavold 1 , Jonathan C Kagan 1
Affiliation  

Pyroptosis is an inflammatory cell death response initiated by supramolecular organizing centers known as inflammasomes. In a recent issue of Science, Rühl et al. (2018) challenge the paradigm that inflammasome signaling necessitates pyroptosis by demonstrating that ESCRTIII-dependent membrane repair can delay or prevent gasdermin D-mediated cell death.

中文翻译:

战胜死亡:关于GSDMD毛孔命运的(W)真相。

细胞凋亡是由称为炎症小体的超分子组织中心引发的炎性细胞死亡反应。在最近一期的《科学》杂志中,Rühl等人。(2018)通过证明依赖于ESCRTIII的膜修复可以延迟或预防加德明D介导的细胞死亡来挑战炎性体信号转导必须进行细胞凋亡的范例。
更新日期:2019-01-15
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