Defining pathways that differentially regulate graft-reactive versus anti-microbial T cell responses could facilitate more precise manipulation of immune responses in the context of organ and tissue transplantation. Here, Jayachandran et al. (2019) identify a coronin-1-PDE4-cAMP axis that, when perturbed, results in the induction of transplantation tolerance while maintaining anti-microbial immunity.

中文翻译：

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Coronin-1，同种免疫之王

定义差异调节移植物反应性与抗微生物 T 细胞反应的途径可以促进在器官和组织移植的情况下更精确地操纵免疫反应。在这里，Jayachandran 等人。(2019) 确定了一个 coronin-1-PDE4-cAMP 轴，当它受到干扰时，会导致移植耐受性的诱导，同时保持抗微生物免疫。