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Injectable Slippery Lubricant-Coated Spiky Microparticles with Persistent and Exceptional Biofouling-Resistance
ACS Central Science ( IF 12.7 ) Pub Date : 2019-01-14 00:00:00 , DOI: 10.1021/acscentsci.8b00605 Chengduan Yang 1 , Gen He 1 , Aihua Zhang 1 , Qianni Wu 1 , Lingfei Zhou 1 , Tian Hang 1 , Di Liu 2 , Shuai Xiao 1 , Hui-Jiuan Chen 1 , Fanmao Liu 1 , Linxian Li 3 , Ji Wang 1 , Xi Xie 1
ACS Central Science ( IF 12.7 ) Pub Date : 2019-01-14 00:00:00 , DOI: 10.1021/acscentsci.8b00605 Chengduan Yang 1 , Gen He 1 , Aihua Zhang 1 , Qianni Wu 1 , Lingfei Zhou 1 , Tian Hang 1 , Di Liu 2 , Shuai Xiao 1 , Hui-Jiuan Chen 1 , Fanmao Liu 1 , Linxian Li 3 , Ji Wang 1 , Xi Xie 1
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Injectable micron-sized particles have historically achieved promising applications, but they continued to suffer from long-term biofouling caused by the adhesions of biomolecules, cells, and bacteria. Recently, a slippery lubricant infusion porous substrate (SLIPS) exhibited robust antiadhesiveness against many liquids; however, they were constructed using a 2D substrate, and they were not suitable for in vivo applications, such as injectable biomaterials. Inspired by SLIPS, here, we report the first case of injectable solid microparticles coated with a lubricating liquid surface to continuously resist biofouling. In our design, microparticles were attached with nanospikes and fluorinated to entrap the lubricant. The nanospikes enabled the lubricant-coated spiky microparticles (LCSMPs) to anomalously disperse in water despite the attraction between the surfaces of the microparticles. This result indicated that the LCSMPs exhibited persistent anomalous dispersity in water while maintaining a robust lubricating surface layer. LCSMPs prevented the adhesion of proteins, mammalian cells, and bacteria, including Escherichia coli and Staphylococcus aureus. LCSMPs also reduced in vivo fibrosis while conventional microparticles were heavily biofouled. This technology introduced a new class of injectable anti-biofouling microparticles with reduced risks of inflammation and infections.
中文翻译：
可注射的光滑润滑剂涂层尖刺微粒具有持久且卓越的抗生物污垢性
可注射微米级颗粒历来取得了有前景的应用，但它们仍然受到生物分子、细胞和细菌粘附引起的长期生物污垢的困扰。最近，一种光滑的润滑剂灌注多孔基材（SLIPS）对许多液体表现出强大的抗粘附性；然而，它们是使用 2D 基底构建的，不适合体内应用，例如可注射生物材料。受 SLIPS 的启发，我们在此报告了首个涂有润滑液体表面的可注射固体微粒的案例，以持续抵抗生物污垢。在我们的设计中，微粒附着有纳米尖峰并氟化以捕获润滑剂。尽管微粒表面之间存在吸引力，但纳米尖刺使得涂有润滑剂的尖刺微粒（LCSMP）能够异常地分散在水中。这一结果表明，LCSMP 在水中表现出持续的异常分散性，同时保持坚固的润滑表面层。LCSMP 可以阻止蛋白质、哺乳动物细胞和细菌（包括大肠杆菌和金黄色葡萄球菌）的粘附。LCSMP 还可以减少体内纤维化，而传统微粒则严重生物污染。该技术引入了新型可注射抗生物污染微粒，可降低炎症和感染的风险。
更新日期：2019-01-14
中文翻译：
可注射的光滑润滑剂涂层尖刺微粒具有持久且卓越的抗生物污垢性
可注射微米级颗粒历来取得了有前景的应用，但它们仍然受到生物分子、细胞和细菌粘附引起的长期生物污垢的困扰。最近，一种光滑的润滑剂灌注多孔基材（SLIPS）对许多液体表现出强大的抗粘附性；然而，它们是使用 2D 基底构建的，不适合体内应用，例如可注射生物材料。受 SLIPS 的启发，我们在此报告了首个涂有润滑液体表面的可注射固体微粒的案例，以持续抵抗生物污垢。在我们的设计中，微粒附着有纳米尖峰并氟化以捕获润滑剂。尽管微粒表面之间存在吸引力，但纳米尖刺使得涂有润滑剂的尖刺微粒（LCSMP）能够异常地分散在水中。这一结果表明，LCSMP 在水中表现出持续的异常分散性，同时保持坚固的润滑表面层。LCSMP 可以阻止蛋白质、哺乳动物细胞和细菌（包括大肠杆菌和金黄色葡萄球菌）的粘附。LCSMP 还可以减少体内纤维化，而传统微粒则严重生物污染。该技术引入了新型可注射抗生物污染微粒，可降低炎症和感染的风险。
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