Benzoquinone ansamycins are known to be potent Heat shock protein (Hsp90) inhibitors, and total-synthesis-based structure modification of this natural product family may lead to the discovery of novel cancer chemotherapeutics. Described in this paper is a unified synthetic route that gives access to both natural and C-8-modified C5-C15 fragments of this natural product family.

中文翻译：

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基于全合成的苯醌安沙霉素抗生素修饰：C5-C15片段的C8多样化

苯醌醌沙霉素是有效的热休克蛋白（Hsp90）抑制剂，该天然产物家族的基于全合成的结构修饰可能导致发现新的癌症化学治疗剂。本文描述的是一条统一的合成路线，该路线可访问该天然产物家族的天然和C-8修饰的C5-C15片段。