The first stereoselective total synthesis of antibiotic macrolide Berkeleylactone F is described. The synthetic sequence notably features Sharpless kinetic resolution to access chiral epoxide followed by its regioselective ring-opening reaction, Sharpless asymmetric reaction and ring-closing metathesis.

中文翻译：

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首个立体选择性全合成抗生素大环内酯伯克利内酯F

描述了抗生素大环内酯伯克利内酯F​​的第一个立体选择性全合成。合成序列的显着特征是通过Sharpless动力学拆分获得手性环氧化物，然后进行区域选择性开环反应，Sharpless不对称反应和闭环复分解反应。