Polysaccharides from fermented Momordica charantia ameliorate obesity in high-fat induced obese rats†,Food & Function

当前位置： X-MOL 学术 › Food Funct. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Polysaccharides from fermented Momordica charantia ameliorate obesity in high-fat induced obese rats†
Food & Function ( IF 5.1 ) Pub Date : 2019-01-10 00:00:00 , DOI: 10.1039/c8fo01609g
Jia-Jia Wen _{1,

2,

3,

4} , He Gao _{1,

2,

3,

4} , Jie-Lun Hu _{1,

2,

3,

4} , Qi-Xing Nie _{1,

2,

3,

4} , Hai-Hong Chen _{1,

2,

3,

4} , Tao Xiong _{1,

2,

3,

4} , Shao-Ping Nie _{1,

2,

3,

4} , Ming-Yong Xie _{1,

2,

3,

4}

Affiliation

Momordica charantia (M. charantia) has been widely used to treat obesity due to its bioactive ingredients. This research aimed to investigate the anti-obesity effect of polysaccharides (FP) from fermented M. charantia with Lactobacillus plantarum NCU116 on high-fat induced obese rats. We found that FP could effectively lower the body weight gain, Lee's index, insulin resistance and cell sizes of epididymal adipose tissues in obese rats compared with polysaccharides from non-fermented M. charantia (NFP). FP treatments decreased the total cholesterol, triacylglycerols, and low-density lipoprotein cholesterol, leptin, whereas they elevated the high-density lipoprotein cholesterol, adiponectin, significantly in the serum of obese rats. Furthermore, administrations of FP notably improved oxidative balance in obese rats. Lipidomics results indicated that 24 potential biomarkers have been identified in serum. Additionally, 21 lipids were considerably altered by FP and NFP intakes, such as fatty acyls, glycerolipids, sphingolipids, sterol lipids and glycerophospholipids. The anti-obesity properties of FP were revealed via relieving insulin resistance and fat accumulation of obese rats, which was associated with the regulation of lipid metabolism. Overall, FP exerted more favourable impacts on the anti-obesity effect than NFP, which may be attributed to fermentation.

中文翻译：

苦瓜发酵后的多糖可改善高脂诱导的肥胖大鼠的肥胖†

苦瓜（M. charantia）由于其生物活性成分而被广泛用于治疗肥胖症。这项研究旨在调查发酵的M. charantia与植物乳杆菌NCU116的多糖（FP）对高脂诱导的肥胖大鼠的抗肥胖作用。我们发现，与未发酵的M. charantia多糖相比，FP可以有效降低肥胖大鼠的体重增加，Lee指数，胰岛素抵抗和附睾脂肪组织的细胞大小。（NFP）。FP治疗降低了肥胖大鼠血清中的总胆固醇，三酰基甘油和低密度脂蛋白胆固醇瘦素，而它们却显着升高了高密度脂蛋白胆固醇脂联素。此外，FP的施用显着改善了肥胖大鼠中的氧化平衡。脂质组学结果表明，在血清中已鉴定出24种潜在的生物标志物。此外，FP和NFP摄入量极大地改变了21种脂质，例如脂肪酰基，甘油脂，鞘脂，固醇脂和甘油磷脂。FP的抗肥胖特性通过减轻肥胖大鼠的胰岛素抵抗和脂肪积累，这与脂质代谢的调节有关。总体而言，与NFP相比，FP对抗肥胖作用产生了更有利的影响，这可能归因于发酵。

更新日期：2019-01-10

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11