Conflicting results have been reported regarding human herpes virus (HHV) reactivation in patients with rheumatoid arthritis (RA). To explore this link, 74 RA patients were selected and compared to 42 first degree relatives (FDR) from probands with RA and 25 healthy controls from the Tatarstan women cohort. The serological analysis was done by testing anti-HSV/CMV/EBV IgM, IgG, plus the IgG avidity index, and completed by evaluating HSV/CMV/EBV DNA by PCR. Results from these analyses reveal: (i) a long lasting infection of HHV in RA, FDR and healthy controls (IgG seroconversion >97%); (ii) an elevated IgM anti-HHV response in seroconverted RA patients which is related to HSV1/2 reactivation (HSV1/2 PCR+); and (iii) a multi-reactive IgM HHV burden profile associated with disease activity (DAS28). In conclusion, HSV1/2 reactivation in seroconverted RA patients is associated with an abnormal anti-HHV immune response, which was reflected in IgM HHV burden, and in activity disease profile.

中文翻译：

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在血清转化的类风湿关节炎患者中，多反应性抗疱疹IgM谱与疾病活动有关。

关于类风湿关节炎（RA）患者的人类疱疹病毒（HHV）活化的报道相矛盾。为了探索这一联系，选择了74名RA患者，并将其与来自RA先证者的42名一级亲属（FDR）和来自tar斯坦妇女队列的25名健康对照进行比较。血清学分析通过测试抗HSV / CMV / EBV IgM，IgG和IgG亲和力指数完成，并通过PCR评估HSV / CMV / EBV DNA来完成。这些分析的结果表明：（i）RA，FDR和健康对照长期感染HHV（IgG血清转化率> 97％）；（ii）血清转化的RA患者的IgM抗HHV反应升高，这与HSV1 / 2重新激活（HSV1 / 2 PCR +）有关；（iii）与疾病活动相关的多反应性IgM HHV负担特征（DAS28）。综上所述，