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A phytochemical investigation of Stemona parviflora roots reveals several compounds with nematocidal activity
Phytochemistry ( IF 3.8 ) Pub Date : 2019-03-01 , DOI: 10.1016/j.phytochem.2018.12.021
Sheng-Zhuo Huang , Fan-Dong Kong , Gao Chen , Xiang-Hai Cai , Li-Man Zhou , Qing-Yun Ma , Qi Wang , Wen-Li Mei , Hao-Fu Dai , You-Xing Zhao

Twelve undescribed compounds including six phenanthrene derivatives (parviphenanthrines A-F), two stilbene derivatives (parvistilbines A-B), three esters (parviesters A-C), and one sesquiterpenoid (parvidiol A) were isolated from the roots of Stemona parviflora, together with twenty-two known ones. The structures of the undescribed compounds were elucidated based on the analyses of their spectroscopic data. The absolute configuration of parviphenanthrine A was determined by the quantum ECD calculations. Parviphenanthrines A and E, stemanthrene A, stilbostenin E, 4-hydroxy-benzenepropanol-α-benzoate, and (E)-4-hydroxycinnamic acid methyl ester showed nematocidal activity against Meloidogyne incognita with IC50 values of 14.02 ± 0.32, 2.51 ± 0.13, 17.10 ± 0.65, 2.05 ± 0.07, 4.22 ± 0.31, and 1.07 ± 0.05 μM, respectively.

中文翻译:

对小花百合根的植物化学研究揭示了几种具有杀线虫活性的化合物

从小花百合根中分离出 12 种未描述的化合物,包括六种菲衍生物 (parviphenanthrines AF)、两种芪衍生物 (parvistilbines AB)、三种酯类 (parviesters AC) 和一种倍半萜类化合物 (parvidiol A),以及 22 种已知化合物. 基于对它们的光谱数据的分析,阐明了未描述化合物的结构。parviphenanthrine A 的绝对构型由量子 ECD 计算确定。Parviphenanthrines A 和 E、steranthrene A、stilbostenin E、4-羟基-苯丙醇-α-苯甲酸酯和 (E)-4-羟基肉桂酸甲酯对南方根结线虫具有杀线虫活性,IC50 值为 14.02 ± 0.32, 2.51, ± 0分别为 17.10 ± 0.65、2.05 ± 0.07、4.22 ± 0.31 和 1.07 ± 0.05 μM。
更新日期:2019-03-01
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