"New Therapeutic Targets" is the theme of articles in the Annual Review of Pharmacology and Toxicology, Volume 59. Reviews in this volume discuss targets for a variety of conditions in need of new therapies, including type 2 diabetes, heart failure with preserved ejection fraction, obesity, thyroid-associated ophthalmopathy, tinnitus, multiple sclerosis, Parkinson's disease and other neurodegenerative diseases, pain, depression, post-traumatic stress disorder, muscle wasting diseases, cancer, and anemia associated with chronic renal disease. Numerous articles in this volume focus on the identification, validation, and utility of novel therapeutic targets, in particular, ones that involve new or unexpected molecular entities. This theme complements several previous themes, including "New Approaches for Studying Drug and Toxicant Action: Applications to Drug Discovery and Development," "Precision Medicine and Prediction in Pharmacology," and "New Methods and Novel Therapeutic Approaches in Pharmacology and Toxicology."

中文翻译：

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介绍主题“新的治疗目标”。

“新治疗目标”是《药理与毒理学年度评论》第59卷中的文章主题。该卷中的讨论讨论了需要新疗法的各种疾病的目标，包括2型糖尿病，射血分数保留的心力衰竭，肥胖，甲状腺相关性眼病，耳鸣，多发性硬化，帕金森氏病和其他神经退行性疾病，疼痛，抑郁，创伤后应激障碍，肌肉萎缩性疾病，癌症以及与慢性肾脏病相关的贫血。本卷中的许多文章着重于新型治疗靶标的鉴定，验证和实用性，特别是涉及新的或意想不到的分子实体的靶标。该主题是先前几个主题的补充，其中包括“