Obesity is a worldwide pandemic in adults as well as children and adds greatly to health care costs through its association with type 2 diabetes, metabolic syndrome, cardiovascular disease, and cancers. The prevailing medical view of obesity is that it results from a simple imbalance between caloric intake and energy expenditure. However, numerous other factors are important in the etiology of obesity. The obesogen hypothesis proposes that environmental chemicals termed obesogens promote obesity by acting to increase adipocyte commitment, differentiation, and size by altering metabolic set points or altering the hormonal regulation of appetite and satiety. Many obesogens are endocrine disrupting chemicals that interfere with normal endocrine regulation. Endocrine disrupting obesogens are abundant in our environment, used in everyday products from food packaging to fungicides. In this review, we explore the evidence supporting the obesogen hypothesis, as well as the gaps in our knowledge that are currently preventing a complete understanding of the extent to which obesogens contribute to the obesity pandemic.

中文翻译：

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环境致肥胖物：机制和争议。

肥胖症是成年人和儿童中的全球性大流行，并且由于肥胖与2型糖尿病，代谢综合症，心血管疾病和癌症有关，因此大大增加了医疗保健费用。医学上普遍认为的肥胖症是由热量摄入和能量消耗之间的简单不平衡引起的。但是，许多其他因素在肥胖的病因中也很重要。肥胖原假说提出，被称为肥胖原的环境化学物质通过改变代谢设定点或改变食欲和饱腹感的激素调节来增加脂肪细胞的摄取，分化和大小，从而促进肥胖。许多致病原是干扰内分泌的化学物质，会干扰正常的内分泌调节。内分泌破坏性致病菌在我们的环境中非常丰富，用于从食品包装到杀菌剂的日常产品。在这篇综述中，我们探讨了支持肥胖原假说的证据，以及我们目前尚无法完全了解肥胖原在多大程度上导致肥胖大流行的知识方面的不足。