Impulse control disorders (ICDs) in Parkinson’s disease (PD) are associated with dopaminergic dysfunction and treatment, but have no satisfactory therapeutic solution. While studies assessing the neurofunctional bases of ICDs are important for advancing our understanding and management of ICDs, they remain sparse and inconsistent. Based on a systematic analysis of the neuroimaging literature, the present review pinpoints various abnormalities beyond the mesocorticolimbic circuit that supports reward processing, suggesting possible dysfunction at the sensorimotor, executive and affective levels. We advocate that: 1) Future studies should use more sophisticated psychological models and behavioral designs that take into account the potentially multifaceted aspect of ICDs; this would allow a more accurate assessment of the underlying neurocognitive processes, which are not all dependent on the dopaminergic system. 2) Future neuroimaging studies should rely more strongly on task-based, event-related analyses to disentangle the various mechanisms that can be dysfunctional in ICDs. We believe these guidelines constitute a prerequisite towards distinguishing causes, correlates and individual susceptibility factors of PD patients with ICDs.

帕金森氏病（PD）的冲动控制障碍（ICD）与多巴胺能功能障碍和治疗有关，但尚无令人满意的治疗方案。尽管评估ICD的神经功能基础的研究对于增进我们对ICD的理解和管理很重要，但它们仍然稀疏且前后不一致。在对神经影像文献进行系统分析的基础上，本综述指出了中皮层皮质回路以外的各种异常现象，这些异常现象支持奖赏过程，提示在感觉运动，执行力和情感水平可能存在功能障碍。我们主张：1）未来的研究应使用更复杂的心理学模型和行为设计，并考虑到ICD的潜在多方面因素；这将允许对潜在的神经认知过程进行更准确的评估，而这些过程并不都依赖于多巴胺能系统。2）未来的神经影像学研究应更加依赖于基于任务的，与事件相关的分析，以弄清各种可能导致ICD功能障碍的机制。我们认为，这些指南构成了区分具有ICD的PD患者的原因，相关性和个体敏感性因素的先决条件。