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Current status and contemporary approaches to the discovery of antitumor agents from higher plants.
Biotechnology Advances ( IF 12.1 ) Pub Date : 2019-01-08 , DOI: 10.1016/j.biotechadv.2019.01.004
Garima Agarwal 1 , Peter J Blanco Carcache 1 , Ermias Mekuria Addo 1 , A Douglas Kinghorn 1
Affiliation  

Higher plant constituents have afforded clinically available anticancer drugs. These include both chemically unmodified small molecules and their synthetic derivatives currently used or those in clinical trials as antineoplastic agents, and an updated summary is provided. In addition, botanical dietary supplements, exemplified by mangosteen and noni constituents, are also covered as potential cancer chemotherapeutic agents. Approaches to metabolite purification, rapid dereplication, and biological evaluation including analytical hyphenated techniques, molecular networking, and advanced cellular and animal models are discussed. Further, enhanced and targeted drug delivery systems for phytochemicals, including micelles, nanoparticles and antibody drug conjugates (ADCs) are described herein.



中文翻译:

从高等植物中发现抗肿瘤药的现状和当代方法。

高等植物成分提供了临床上可用的抗癌药。这些既包括目前未使用的化学未修饰的小分子及其合成衍生物,也包括在临床试验中用作抗肿瘤药的衍生物,并提供了更新的摘要。此外,以山竹和诺丽成分为例的植物性膳食补充剂也被列为潜在的癌症化学治疗剂。讨论了代谢物纯化,快速重复复制和生物学评估的方法,包括分析连接技术,分子网络以及先进的细胞和动物模型。此外,本文描述了用于植物化学物质的增强的和靶向的药物递送系统,包括胶束,纳米颗粒和抗体药物缀合物(ADC)。

更新日期:2019-01-08
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