BACKGROUND Patients with anorexia nervosa (AN) have altered physiologic responses to exercise. The aim of this study was to investigate exercise capacity and ventricular function during exercise in adolescent patients with AN. METHODS Sixty-six adolescent female patients with AN and 21 adolescent female control subjects who exercised to volitional fatigue on a semisupine ergometer, using an incremental step protocol of 20 W every 3 min, were retrospectively studied. Heart rate, blood pressure, and echocardiographic Doppler indices were measured at rest and during each stage of exercise. Fractional shortening, rate-corrected mean velocity of circumferential fiber shortening, stress at peak systole, cardiac output, and cardiac index were calculated. Minute ventilation, oxygen consumption, carbon dioxide production, and respiratory exchange ratio were measured using open-circuit spirometry. RESULTS Patients with AN had significantly lower body mass index (16.7 vs 19.7 kg/m2, P < .001), total work (1,126 vs 1,914 J/kg, P < .001), and test duration (13.8 vs 20.8 min, P < .001) compared with control subjects. Peak minute ventilation, oxygen consumption, and carbon dioxide production were significantly decreased in patients with AN. Heart rate, systolic blood pressure, cardiac index, fractional shortening, and rate-corrected mean velocity of circumferential fiber shortening demonstrated similar patterns of increase with progressive exercise between groups but were decreased at peak exercise in patients with AN. Body mass index percentile, age, peak oxygen consumption, and peak cardiac output were independently associated with exercise duration. CONCLUSIONS Adolescent patients with AN have reduced exercise capacity and peak cardiovascular indices compared with control subjects but normal patterns of cardiovascular response during progressive exercise. Systolic ventricular function is maintained during exercise in adolescents with AN.

中文翻译：

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青春期女性神经性厌食症患者运动期间心室功能的超声心动图评估。

背景神经性厌食症（AN）的患者改变了对运动的生理反应。这项研究的目的是调查青少年AN患者运动期间的运动能力和心室功能。方法回顾性研究了66名青春期女性患者和21名青春期女性对照对象，他们在半仰卧起坐测力计上进行自愿性疲劳，每3分钟使用20 W的增量步进方案。在休息和运动的每个阶段都测量心率，血压和超声心动图多普勒指数。计算分数缩短，周向纤维缩短的速率校正平均速度，峰值收缩压，心输出量和心指数。分钟通风，氧气消耗，二氧化碳的产生，使用开路肺活量测定法测量呼吸和呼吸交换率。结果AN患者的体重指数（16.7 vs 19.7 kg / m2，P <.001），总工作量（1,126 vs 1,914 J / kg，P <.001）和测试时间（13.8 vs 20.8 min，P <.001）与对照组比较。AN患者的峰值通气量，耗氧量和二氧化碳生成量显着降低。心率，收缩压，心脏指数，缩短分数，以及经校正的圆周纤维缩短的平均速度在两组之间随渐进运动表现出相似的增加模式，但在AN患者中达到高峰运动时下降。体重指数百分位数，年龄，峰值耗氧量和峰值心输出量与运动时间独立相关。结论与对照组相比，患有AN的青春期患者的运动能力降低，心血管指数达到峰值，但在进行性运动过程中心血管反应的正常模式。患有AN的青少年在运动过程中维持收缩期心室功能。